Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein

• Published in: Experimental hematology Vol. 29; no. 9; pp. 1082 - 1090
• Main Authors: Ergin, Melek, Denning, Mitchell F, Izban, Keith F, Amin, Hesham M, Martinez, Robert L, Saeed, Shahnaz, Alkan, Serhan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.09.2001
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Benzamides; Benzoquinones; Caspases - pharmacology; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 5; Enzyme Inhibitors - pharmacology; Hodgkin Disease - pathology; Humans; Imatinib Mesylate; Immunohistochemistry; Lactams, Macrocyclic; Lymphoma, Large B-Cell, Diffuse - pathology; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Phosphorylation; Piperazines - pharmacology; Protein-Tyrosine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Pyrimidines - pharmacology; Quinones - pharmacology; Receptor Protein-Tyrosine Kinases; Rifabutin - analogs & derivatives; Translocation, Genetic; Tumor Cells, Cultured - drug effects

The t(2;5)(p23;q35) translocation creates a fusion gene NPM-ALK (p80) that encodes a product with tyrosine kinase activity believed to play an important role in development of anaplastic large cell lymphoma (ALCL). Our study was aimed to analyze tyrosine kinase activity and phosphotyrosine in ALCLs....