The use of the micronucleus test and comet assay in wild rodents: a historical review and future perspectives

• Published in: Environmental monitoring and assessment Vol. 196; no. 8; p. 773
• Main Authors: Claro, Hermes Willyan Parreira, Hannibal, Wellington, Benvindo-Souza, Marcelino, de Melo e Silva, Daniela
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2024; Springer Nature B.V
• Subjects: Animal models; Animals; Animals, Wild; Assaying; Atmospheric Protection/Air Quality Control/Air Pollution; Bioassays; Bioindicators; blood; Bone marrow; Brazil; Bulgaria; Comet assay; Comet Assay - methods; Damage detection; DNA Damage; Earth and Environmental Science; Ecology; Ecotoxicology; Environment; environmental exposure; Environmental Management; Environmental Monitoring - methods; Environmental Pollutants - toxicity; Environmental quality; Genotoxicity; genus; Historical account; Indicator species; Italy; Mexico; micronucleus tests; Micronucleus Tests - methods; Monitoring/Environmental Analysis; mutagens; occupations; Review; Rodentia; Rodents; Spain; species; Standardization; Toxicity tests; xenobiotics; South America; Czech Republic; Sweden; Europe; Brazil; Italy; Mexico; Bulgaria; Spain; Wild rodents; Environmental pollution; Bioindicator species; DNA damage; Blood; Heavy metals

Rodents are considered good models for investigating genotoxic damage and mutagenic alterations caused by xenobiotic agents, due to their occupation of a wide variety of habitats. However, relatively few in situ studies have focused on DNA damage in wild rodents associated with environmental exposur...