Association Between Arsenic Toxicity, AS3MT Gene Polymorphism and Onset of Type 2 Diabetes

• Published in: Biological trace element research Vol. 202; no. 4; pp. 1550 - 1558
• Main Authors: Shokat, Saima, Iqbal, Riffat, Riaz, Samreen, Yaqub, Atif
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2024; Springer Nature B.V
• Subjects: Alleles; Arsenic; Biochemistry; Biomedical and Life Sciences; Biotechnology; blood; Diabetes; Diabetes mellitus (non-insulin dependent); Drinking water; Exposure; Gene frequency; Gene polymorphism; genes; genotype; Genotypes; Genotyping; Life Sciences; Metabolism; noninsulin-dependent diabetes mellitus; Nucleotides; Nutrition; Oncology; Pakistan; Polymorphism; Public health; Single-nucleotide polymorphism; Toxicity; urine; Pakistan; Type 2 diabetes; Drinking water; Arsenic toxicity; gene; Water contamination; AS3MT gene

Arsenic (As) exposure in drinking water has become a serious public health issue. AS3MT gene is involved in the metabolism of arsenic, so a single nucleotide polymorphism in this gene may lead to the development of type 2 diabetes in arsenic-exposed areas. This study aimed to evaluate the associatio...