Isolation of a kidney-specific peptide recognized by alloreactive HLA- A3-restricted human CTL

• Published in: The Journal of immunology (1950) Vol. 154; no. 8; pp. 3880 - 3887
• Main Authors: Poindexter, NJ, Naziruddin, B, McCourt, DW, Mohanakumar, T
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.04.1995
• Subjects: Amino Acid Sequence; Autoantigens - immunology; Cytotoxicity, Immunologic; Epitopes; HLA-A3 Antigen - immunology; Humans; In Vitro Techniques; Isoantigens - isolation & purification; Kidney - immunology; Molecular Sequence Data; Oligopeptides - chemistry; Oligopeptides - immunology; T-Lymphocytes, Cytotoxic - immunology

The molecular nature of tissue-specific Ags involved in MHC-restricted CTL responses is as yet undefined. To determine the specificity of these peptides, their function, and their possible relationship to allograft rejection, we have utilized human kidney-specific CD8+ CTL clones to screen reversed-...