MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

• Published in: Molecular cell Vol. 73; no. 6; pp. 1138 - 1149.e6
• Main Authors: Lee, In Young, Lim, Jane Melissa, Cho, Hyunchu, Kim, Eunju, Kim, Yeonsil, Oh, Hye-Kyung, Yang, Woo Seok, Roh, Kyung-Hye, Park, Hyun Woo, Mo, Jung-Soon, Yoon, Je-Hyun, Song, Hyun Kyu, Choi, Eui-Ju
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.03.2019
• Subjects: HOIP; inflammation; LUBAC; macrophage; MST1; NF-κB; TNFα; TNFα receptor 1 signaling complex; TRAF2; ubiquitination; NF-κB; TNFα; ubiquitination; inflammation; MST1; TNFα receptor 1 signaling complex; macrophage; TRAF2; LUBAC; HOIP

The nuclear factor (NF)-κB pathway plays a central role in inflammatory and immune responses, with aberrant activation of NF-κB signaling being implicated in various human disorders. Here, we show that mammalian ste20-like kinase 1 (MST1) is a previously unrecognized component of the tumor necrosis...