The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

• Published in: The Journal of experimental medicine Vol. 215; no. 5; pp. 1287 - 1299
• Main Authors: Li, Tuo, Chen, Zhijian J.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 07.05.2018
• Subjects: Activation; Adenosine monophosphate; AMP; Cancer; Cyclic GMP; Damage detection; Deoxyribonucleic acid; DNA; DNA damage; Genomic instability; Guanosine; Immune response; Immune system; Inflammation; Innate immunity; Microorganisms; Nucleotide sequence; Reviews; Senescence; Stability

Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host immune system to mount a defense response to microbial infections. However, this detection mechanism also poses a challenge to the host as to how to distinguish foreign DNA from abundant self-DNA. Cyclic guanosi...