Inhibition of calcium phosphate precipitation by human salivary statherin: structure-activity relationships

• Published in: Calcified tissue international Vol. 50; no. 6; p. 511
• Main Authors: Schwartz, S S, Hay, D I, Schluckebier, S K
• Format: Journal Article
• Language: English
• Published: United States 01.06.1992
• Subjects: Amino Acid Sequence; Calcium Phosphates - chemistry; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Humans; Molecular Sequence Data; Peptides - chemistry; Peptides - pharmacology; Salivary Proteins and Peptides - chemistry; Salivary Proteins and Peptides - isolation & purification; Salivary Proteins and Peptides - pharmacology; Structure-Activity Relationship

Previous studies of human statherin showed the active region for inhibition of secondary calcium phosphate precipitation (crystal growth) to reside in the highly charged amino-terminal one-third of this molecule, and the neutral tyrosine-, glutamine- and proline-rich carboxy-terminal two-thirds of t...