Inflammasome functional activities in B lymphocytes

• Published in: Immunologic research Vol. 72; no. 4; pp. 828 - 840
• Main Authors: Hsu, Man Lun, Jhuang, Kai Fu, Zouali, Moncef
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2024; Springer Nature B.V
• Subjects: Adaptive Immunity; Allergology; Animal models; Animals; antibody formation; B-lymphocytes; B-Lymphocytes - immunology; Biomedical and Life Sciences; Biomedicine; Caspase-1; Cell activation; Cells, Cultured; Cytokines; Cytokines - metabolism; Humans; Immunity, Innate; Immunology; Inflammasomes; Inflammasomes - immunology; Inflammasomes - metabolism; Inflammation; Innate immunity; Internal Medicine; Leukocytes (neutrophilic); Lymphocyte Activation - immunology; Lymphocytes B; Lymphocytes T; Macrophages; Medicine/Public Health; Mice; Mice, Inbred C57BL; Mice, Knockout; neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Oligomerization; Pyrin protein; Pyroptosis; Receptor mechanisms; secretion; Toll-like receptors; B cell; NLRP3; Innate immunity; Inflammasome; Adaptive immunity

Studies in animal models and human subjects have shown that, in addition to their implication in innate immunity, inflammasomes also can play a role in adaptive immunity. However, the contribution of the nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing pr...