MicroRNAs (miRNAs) in Cardiovascular Complications of Rheumatoid Arthritis (RA): What Is New?

Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by...

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Published inInternational journal of molecular sciences Vol. 23; no. 9; p. 5254
Main Authors Tanase, Daniela Maria, Gosav, Evelina Maria, Petrov, Daniela, Teodorescu, Dan-Stefan, Buliga-Finis, Oana Nicoleta, Ouatu, Anca, Tudorancea, Ionut, Rezus, Elena, Rezus, Ciprian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.05.2022
MDPI
Subjects
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Atherosclerosis
Autoimmune diseases
Biomarkers
Biomarkers - metabolism
cardiovascular complications
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - genetics
Coronaviruses
COVID-19
CVD
Heart Diseases - complications
Humans
Immunology
Inflammation
Inflammation - complications
Inflammation - genetics
MicroRNAs
MicroRNAs - metabolism
miRNA
miRNAs
Morbidity
Pathogenesis
Review
Rheumatoid arthritis
Therapeutic targets
CVD
atherosclerosis
microRNAs
miRNAs
pericarditis
myocardial infarction
cardiovascular complications
rheumatoid arthritis
RA
Online AccessGet full text

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Abstract Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by a combination between genetic susceptibility, and environmental triggers, which result in an auto-perpetuating process. The subsequently, systemic inflammation associated with RA is linked with a variety of extra-articular comorbidities, including cardiovascular disease (CVD), resulting in increased mortality and morbidity. Hitherto, vast evidence demonstrated the key role of non-coding RNAs such as microRNAs (miRNAs) in RA, and in RA-CVD related complications. In this descriptive review, we aim to highlight the specific role of miRNAs in autoimmune processes, explicitly on their regulatory roles in the pathogenesis of RA, and its CV consequences, their main role as novel biomarkers, and their possible role as therapeutic targets.
AbstractList Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that recognizes both immunological activation and inflammatory pathways, the exact cause of RA remains unclear. It seems however, that RA is initiated by a combination between genetic susceptibility, and environmental triggers, which result in an auto-perpetuating process. The subsequently, systemic inflammation associated with RA is linked with a variety of extra-articular comorbidities, including cardiovascular disease (CVD), resulting in increased mortality and morbidity. Hitherto, vast evidence demonstrated the key role of non-coding RNAs such as microRNAs (miRNAs) in RA, and in RA-CVD related complications. In this descriptive review, we aim to highlight the specific role of miRNAs in autoimmune processes, explicitly on their regulatory roles in the pathogenesis of RA, and its CV consequences, their main role as novel biomarkers, and their possible role as therapeutic targets.
Author Buliga-Finis, Oana Nicoleta
Petrov, Daniela
Ouatu, Anca
Teodorescu, Dan-Stefan
Rezus, Elena
Gosav, Evelina Maria
Tudorancea, Ionut
Rezus, Ciprian
Tanase, Daniela Maria
AuthorAffiliation 6 Cardiology Clinic, “St. Spiridon” County Clinical Emergency Hospital, 700111 Iasi, Romania
5 Department of Morpho-Functional Sciences II, Discipline of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; ionut.tudorancea@umfiasi.ro
1 Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; tanasedm@gmail.com (D.M.T.); dan-stefan.teodorescu@d.umfiasi.ro (D.-S.T.); oana_finish@yahoo.com (O.N.B.-F.); ank_mihailescu@yahoo.com (A.O.); ciprianrezus@yahoo.com (C.R.)
4 I Rheumatology Clinic, Clinical Rehabilitation Hospital, 700661 Iasi, Romania
3 Department of Rheumatology and Physiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, Romania; danielapetrovdoc@gmail.com (D.P.); elena_rezus@yahoo.com (E.R.)
2 Internal Medicine Clinic, “St. Spiridon” County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35563643$$D View this record in MEDLINE/PubMed
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Keywords CVD
atherosclerosis
microRNAs
miRNAs
pericarditis
myocardial infarction
cardiovascular complications
rheumatoid arthritis
RA
Language English
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Snippet Rheumatoid Arthritis (RA) is among the most prevalent and impactful rheumatologic chronic autoimmune diseases (AIDs) worldwide. Within a framework that...
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SubjectTerms Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - genetics
Atherosclerosis
Autoimmune diseases
Biomarkers
Biomarkers - metabolism
cardiovascular complications
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - genetics
Coronaviruses
COVID-19
CVD
Heart Diseases - complications
Humans
Immunology
Inflammation
Inflammation - complications
Inflammation - genetics
MicroRNAs
MicroRNAs - metabolism
miRNA
miRNAs
Morbidity
Pathogenesis
Review
Rheumatoid arthritis
Therapeutic targets
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Title MicroRNAs (miRNAs) in Cardiovascular Complications of Rheumatoid Arthritis (RA): What Is New?
URI https://www.ncbi.nlm.nih.gov/pubmed/35563643
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Volume 23
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