Advances in Research on the Toxicological Effects of Selenium

Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excess...

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Published inBulletin of environmental contamination and toxicology Vol. 106; no. 5; pp. 715 - 726
Main Authors Lv, Qizhuang, Liang, Xiaomei, Nong, Keyi, Gong, Zifeng, Qin, Ting, Qin, Xinyun, Wang, Daobo, Zhu, Yulin
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2021
Springer Nature B.V
Subjects
Aquatic Pollution
death
Dietary Supplements
Drug development
Earth and Environmental Science
Ecotoxicology
Enriched foods
Environment
Environmental Chemistry
Environmental Health
Fertility
Focused Review
growth and development
Heavy metals
immunity
Metals, Heavy
Micronutrients
Microorganisms
Oxidation
Pharmaceutical Preparations
Pollution
R&D
Research & development
Selenium
Selenium - toxicity
Soil Science & Conservation
Toxicity
Toxicology
Trace Elements
Trace elements (nutrients)
Tumors
Waste Water Technology
Water Management
Water Pollution Control
Selenium (Se)
Toxicological effects
Mechanism
Functional agriculture
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Abstract Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excessive selenium supplementation can cause certain toxic effects on the growth and development of the body and may even result in death in severe cases. At present, increasing attention is being paid to the development and utilization of selenium as a micronutrient, but its potential toxicity tends to be neglected. This study systematically reviews recent research on the toxicological effects of selenium, aiming to provide theoretical references for selenium toxicology-related research and theoretical support for the development of selenium-containing drugs, selenium-enriched dietary supplements, and selenium-enriched foods.
AbstractList Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excessive selenium supplementation can cause certain toxic effects on the growth and development of the body and may even result in death in severe cases. At present, increasing attention is being paid to the development and utilization of selenium as a micronutrient, but its potential toxicity tends to be neglected. This study systematically reviews recent research on the toxicological effects of selenium, aiming to provide theoretical references for selenium toxicology-related research and theoretical support for the development of selenium-containing drugs, selenium-enriched dietary supplements, and selenium-enriched foods.
Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excessive selenium supplementation can cause certain toxic effects on the growth and development of the body and may even result in death in severe cases. At present, increasing attention is being paid to the development and utilization of selenium as a micronutrient, but its potential toxicity tends to be neglected. This study systematically reviews recent research on the toxicological effects of selenium, aiming to provide theoretical references for selenium toxicology-related research and theoretical support for the development of selenium-containing drugs, selenium-enriched dietary supplements, and selenium-enriched foods.Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excessive selenium supplementation can cause certain toxic effects on the growth and development of the body and may even result in death in severe cases. At present, increasing attention is being paid to the development and utilization of selenium as a micronutrient, but its potential toxicity tends to be neglected. This study systematically reviews recent research on the toxicological effects of selenium, aiming to provide theoretical references for selenium toxicology-related research and theoretical support for the development of selenium-containing drugs, selenium-enriched dietary supplements, and selenium-enriched foods.
Author Gong, Zifeng
Nong, Keyi
Qin, Ting
Lv, Qizhuang
Zhu, Yulin
Liang, Xiaomei
Qin, Xinyun
Wang, Daobo
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  organization: College of Biology & Pharmacy, Yulin Normal University
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  givenname: Yulin
  surname: Zhu
  fullname: Zhu, Yulin
  email: gxzyl@163.com
  organization: College of Biology & Pharmacy, Yulin Normal University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33420800$$D View this record in MEDLINE/PubMed
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ISSN 0007-4861
1432-0800
IngestDate Fri Jul 11 07:03:18 EDT 2025
Mon Jul 21 12:00:46 EDT 2025
Sat Jul 26 00:40:24 EDT 2025
Mon Jul 21 06:02:07 EDT 2025
Tue Jul 01 04:24:27 EDT 2025
Thu Apr 24 22:53:13 EDT 2025
Fri Feb 21 02:48:25 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Selenium (Se)
Toxicological effects
Mechanism
Functional agriculture
Language English
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PublicationTitle Bulletin of environmental contamination and toxicology
PublicationTitleAbbrev Bull Environ Contam Toxicol
PublicationTitleAlternate Bull Environ Contam Toxicol
PublicationYear 2021
Publisher Springer US
Springer Nature B.V
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SubjectTerms Aquatic Pollution
death
Dietary Supplements
Drug development
Earth and Environmental Science
Ecotoxicology
Enriched foods
Environment
Environmental Chemistry
Environmental Health
Fertility
Focused Review
growth and development
Heavy metals
immunity
Metals, Heavy
Micronutrients
Microorganisms
Oxidation
Pharmaceutical Preparations
Pollution
R&D
Research & development
Selenium
Selenium - toxicity
Soil Science & Conservation
Toxicity
Toxicology
Trace Elements
Trace elements (nutrients)
Tumors
Waste Water Technology
Water Management
Water Pollution Control
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