Genetic effects on planum temporale asymmetry and their limited relevance to neurodevelopmental disorders, intelligence or educational attainment

• Published in: Cortex Vol. 124; pp. 137 - 153
• Main Authors: Carrion-Castillo, Amaia, Pepe, Antonietta, Kong, Xiang-Zhen, Fisher, Simon E., Mazoyer, Bernard, Tzourio-Mazoyer, Nathalie, Crivello, Fabrice, Francks, Clyde
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Ltd 01.03.2020
• Subjects: Autism Spectrum Disorder - genetics; Brain asymmetry; Functional Laterality; Genetic correlation; Genome-wide association; Genome-Wide Association Study; Humans; Intelligence - genetics; Magnetic Resonance Imaging; Neurodevelopmental disorders; Nucleoside-Phosphate Kinase - genetics; Planum temporale; Proteinase Inhibitory Proteins, Secretory - genetics; Proto-Oncogene Proteins c-bcl-2 - genetics; Temporal Lobe; UK biobank; Genetic correlation; Brain asymmetry; UK biobank; Genome-wide association; Neurodevelopmental disorders; Planum temporale

Previous studies have suggested that altered asymmetry of the planum temporale (PT) is associated with neurodevelopmental disorders, including dyslexia, schizophrenia, and autism. Shared genetic factors have been suggested to link PT asymmetry to these disorders. In a dataset of unrelated subjects f...