Study of Estrogen Receptor-α and Receptor-β Gene Polymorphisms on Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 26; no. 3; pp. 431 - 439
• Main Authors: Goumidi, Louisa, Dahlman-Wright, Karin, Tapia-Paez, Isabel, Matsson, Hans, Pasquier, Florence, Amouyel, Philippe, Kere, Juha, Lambert, Jean-Charles, Meirhaeghe, Aline
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2011
• Subjects: Aged; Alzheimer Disease - genetics; Apolipoproteins E - genetics; Case-Control Studies; Estrogen Receptor alpha - genetics; Estrogen Receptor beta - genetics; Female; Genes, Dominant; Genes, Recessive; Genotype; Humans; Linkage Disequilibrium; Male; Molecular Genetics; Molekylär genetik; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Assessment; estrogens; polymorphism; ESR; estrogen receptor; Alzheimer's disease; association study

Estrogen treatment can modulate the risk for developing dementia in women. Therefore, single nucleotide polymorphisms (SNPs) in the estrogen receptor genes may constitute genetic susceptibility factors to Alzheimer's disease (AD). Thus, we investigated the impact of the genetic variability of t...