Severe telomere shortening in Fanconi anemia complementation group L

• Published in: Molecular biology reports Vol. 48; no. 1; pp. 585 - 593
• Main Authors: Shah, Anjali, George, Merin, Dhangar, Somprakash, Rajendran, Aruna, Mohan, Sheila, Vundinti, Babu Rao
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.01.2021; Springer Nature B.V
• Subjects: Adolescent; Adult; Aging; Androgens; Anemia; Animal Anatomy; Animal Biochemistry; biomarkers; Biomedical and Life Sciences; blood; Blood culture; Bone marrow; Child; Child, Preschool; Chromosome Breakage; Complementation; DNA-Binding Proteins - genetics; Fanconi anemia; Fanconi Anemia - genetics; Fanconi Anemia - pathology; Fanconi Anemia Complementation Group A Protein - genetics; Fanconi Anemia Complementation Group G Protein - genetics; Fanconi Anemia Complementation Group L Protein - genetics; Fanconi syndrome; Female; Gene Expression Regulation - genetics; genomics; High-Throughput Nucleotide Sequencing; Histology; Humans; Life Sciences; Male; Malignancy; molecular biology; Morphology; Next-generation sequencing; Original Article; Pancytopenia; Peripheral blood; Polymerase chain reaction; prognosis; quantitative polymerase chain reaction; risk; t-test; Telomere - genetics; Telomere Shortening - genetics; Telomeres; Transplantation; Yeast; Young Adult; qPCR; Fanconi anemia; Chromosomal Instability; Telomere Length
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-020-06101-2

Fanconi Anemia (FA) is a rare genetic disease with the incidence of 1 in 360,000 and is characterised by bone marrow failure, physical abnormalities, pancytopenia, and high frequency of chromosomal breakage and increased risk of evolving into malignancy. Telomere plays an important role in genomic s...