SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase

• Published in: Immunity (Cambridge, Mass.) Vol. 57; no. 3; pp. 587 - 599.e4
• Main Authors: Srivastava, Komal, Carreño, Juan Manuel, Gleason, Charles, Monahan, Brian, Singh, Gagandeep, Abbad, Anass, Tcheou, Johnstone, Raskin, Ariel, Kleiner, Giulio, van Bakel, Harm, Sordillo, Emilia Mia, Alshammary, Hala, Amoako, Angela A., Andre, Dalles, Awawda, Mahmoud, Bermúdez-González, Maria C., Beach, Katherine F., Bielak, Dominika, Cai, Gianna Y., Chernet, Rachel L., Cognigni, Christian, Chen, Yuexing, Eaker, Lily Q., Ferreri, Emily D., Floda, Daniel L., Fried, Miriam, Hamburger, Joshua Z., Jurczyszak, Denise, Kang, Hyun Min, Lyttle, Neko, Matthews, Julia C., Mauldin, Jacob, Mendez, Wanni A., Mischka, Jacob, Morris, Sara, Mulder, Lubbertus C.F., Nabeel, Ismail, Nardulli, Jessica R., Polanco, Jose, Oostenink, Annika, Rooker, Aria, Russo, Kayla T., Salimbangon, Ashley-Beathrese, Saksena, Miti S., Shin, Amber A., Sominsky, Levy A., Stadlbauer, Daniel, Sullivan, Leeba, van Kesteren, Morgan, Yellin, Temima, Wajnberg, Ania, Krammer, Florian, Simon, Viviana
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.03.2024
• Subjects: antibodies; Antibodies, Viral; Antibody Formation; breakthrough infections; COVID-19; COVID-19 vaccines; durability; Humans; hybrid immunity; Immunization, Secondary; longitudinal study; modeling antibody kinetics; mRNA Vaccines; reactogenicity; SARS-CoV-2; SARS-CoV-2 immunity; SARS-CoV-2 variants; Vaccination; Vaccines; COVID-19 vaccines; breakthrough infections; durability; reactogenicity; SARS-CoV-2 variants; antibodies; longitudinal study; SARS-CoV-2 immunity; hybrid immunity; modeling antibody kinetics

It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 infection and vaccination using >8,000 lon...