Formation of an ordered phase by ceramides and diacylglycerols in a fluid phosphatidylcholine bilayer — Correlation with structure and hydrogen bonding capacity

• Published in: Biochimica et biophysica acta Vol. 1848; no. 10; pp. 2111 - 2117
• Main Authors: Ekman, Peik, Maula, Terhi, Yamaguchi, Shou, Yamamoto, Tetsuya, Nyholm, Thomas K.M., Katsumura, Shigeo, Slotte, J.Peter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2015
• Subjects: Ceramides - chemistry; Diglycerides - chemistry; Fluorescence life time analysis; Hydrogen - chemistry; Hydrogen Bonding; Lipid Bilayers - chemistry; Membrane Fluidity; Molecular Conformation; Molecular Dynamics Simulation; Phase separation; Phase Transition; Phosphatidylcholines - chemistry; Solutions; Statistics as Topic; Trans-parinaric acid; Hydrogen bonding; Fluorescence life time analysis; Phase separation; Trans-parinaric acid

Ceramides and diacylglycerols are lipids with a large hydrophobic part (acyl chains and long-chain base) whereas their polar function (hydroxyl group) is small. They need colipids with large head groups to coexist in bilayer membranes. In this study, we have determined how saturated and unsaturated...