Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells

• Published in: The Journal of biological chemistry Vol. 268; no. 11; pp. 7741 - 7746
• Main Author: LINDSTEDT, K. A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 15.04.1993
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Cell Communication; Cells, Cultured; Copper - pharmacology; Copper Sulfate; Cytoplasmic Granules - metabolism; Egtazic Acid - pharmacology; Exocytosis; Fundamental and applied biological sciences. Psychology; Histamine - pharmacology; Humans; Kinetics; Lipoproteins, LDL - metabolism; Lipoproteins, myelin; Macrophages - drug effects; Macrophages - metabolism; Mast Cells - physiology; Mice; Oxidation-Reduction; p-Methoxy-N-methylphenethylamine - pharmacology; Proteins; Proteoglycans - pharmacology; Rats; Thiobarbituric Acid Reactive Substances - analysis; Lipoprotein LDL; Histamine; Vertebrata; Mammalia; Rat; Rodentia; Atherosclerosis; Mast cell; Oxidation; Inhibition; Macrophage

Mast cells and macrophages coexist in the human arterial intima where oxidation of low density lipoproteins (LDL) also takes place during atherosclerosis. To investigate whether mast cells play a role in macrophage-mediated oxidation of LDL, a model system was designed in which mast cells and macrop...