Accelerated aging signatures in subjects with schizophrenia and their unaffected siblings

• Published in: Journal of psychiatric research Vol. 139; pp. 30 - 37
• Main Authors: Rebouças, Diego Barreto, Sartori, Juliana Mastella, Librenza-Garcia, Diego, Rabelo-da-Ponte, Francisco Diego, Massuda, Raffael, Czepielewski, Leticia Sanguinetti, Passos, Ives Cavalcante, Gama, Clarissa Severino
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2021
• Subjects: Accelerated aging; Biomarkers; Endophenotypes; Machine learning; Schizophrenia; Siblings; PCC; Accelerated aging; Endophenotypes; Machine learning; Schizophrenia; Biomarkers; TL; TBARS; GPx; Siblings; ML

Schizophrenia (SZ) is a chronic debilitating disease. Subjects with SZ have significant shorter life expectancy. Growing evidence suggests that a process of pathological accelerated aging occurs in SZ, leading to early development of severe clinical diseases and worse morbimortality. Furthermore, un...