Argonaute proteins: structures and their endonuclease activity

• Published in: Molecular biology reports Vol. 48; no. 5; pp. 4837 - 4849
• Main Authors: Jin, Shujuan, Zhan, Jian, Zhou, Yaoqi
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2021; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Argonaute Proteins - chemistry; Argonaute Proteins - genetics; Argonaute Proteins - metabolism; biogenesis; Biomedical and Life Sciences; Deoxyribonucleic acid; DNA; Endonuclease; Endonucleases - chemistry; Endonucleases - metabolism; Gene Editing; Gene Silencing; genes; Genome editing; Histology; Life Sciences; molecular biology; Morphology; Proteins; Review; RNA; RNA, Guide, CRISPR-Cas Systems; RNA, Small Interfering - metabolism; RNA-mediated interference; MID domain; PIWI domain; Guide; Endonuclease; Argonaute

Argonaute proteins are highly conserved and widely expressed in almost all organisms. They not only play a critical role in the biogenesis of small RNAs but also defend against invading nucleic acids via small RNA or DNA-mediated gene silencing pathways. One functional mechanism of Argonaute protein...