Performance on the Operant Test Battery in young children exposed to procedures requiring general anaesthesia: the MASK study

• Published in: British journal of anaesthesia : BJA Vol. 122; no. 4; pp. 470 - 479
• Main Authors: Warner, David O., Chelonis, John J., Paule, Merle G., Frank, Ryan D., Lee, Minji, Zaccariello, Michael J., Katusic, Slavica K., Schroeder, Darrell R., Hanson, Andrew C., Schulte, Phillip J., Wilder, Robert T., Sprung, Juraj, Flick, Randall P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2019; Elsevier
• Subjects: anaesthetic neurotoxicity; Anesthesia, General - adverse effects; Anesthetics, General - adverse effects; Child; Child Development - drug effects; Child, Preschool; Cluster Analysis; Cognition Disorders - chemically induced; Cognition Disorders - diagnosis; developmental; Factor Analysis, Statistical; Female; Follow-Up Studies; general anaesthesia; Humans; Male; neurodevelopment; Neuropsychological Tests; Neuroscience and Neuroanaesthesia; Operant Test Battery; psychology; developmental; neurodevelopment; psychology; general anaesthesia; Operant Test Battery; anaesthetic neurotoxicity; neuropsychological tests

It is not known whether the neurotoxicity produced by anaesthetics administered to young animals can also occur in children. Exposure of infant macaques to ketamine impairs performance in selected domains of the Operant Test Battery (OTB), which can also be administered to children. This study deter...