The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 12; p. 129722
• Main Authors: Faktor, Jakub, Grasso, Giuseppa, Zavadil Kokas, Filip, Kurkowiak, Małgorzata, Mayordomo, Marcos Yébenes, Kote, Sachin, Singh, Ashita, Ruidong, Li, O'Neill, J. Robert, Muller, Petr, Goodlett, David, Vojtesek, Borek, Hupp, Ted
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020
• Subjects: Cancer; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma - genetics; Mutation; p53; Protein mass spectrometry; Proteogenomics; Proteome - genetics; Proteomics; Tumor Suppressor Protein p53 - genetics; Protein mass spectrometry; Proteogenomics; Proteomics; Cancer; p53

The identification of mutated proteins in human cancer cells-termed proteogenomics, requires several technologically independent research methodologies including DNA variant identification, RNA sequencing, and mass spectrometry. Any one of these methodologies are not optimized for identifying potent...