Immunohistochemical Validation of Rare Tissues and Antigens With Low Frequency of Occurrence: Recommendations From The Anatomic Pathology Patient Interest Association (APPIA)

• Published in: Applied immunohistochemistry & molecular morphology Vol. 29; no. 5; p. 327
• Main Authors: Lott, Robert L, Riccelli, Peter V, Sheppard, Elizabeth A, Wharton, Jr, Keith A, Walk, Eric E, Kennedy, George, Portier, Bryce
• Format: Journal Article
• Language: English
• Published: United States 01.05.2021

Laboratories worldwide find it challenging to identify enough tissues and cases for verification and validation studies of low-incidence, rare antigens. These antigens have a low frequency of occurrence in the population, or have little or no expression in normal tissues. Validation studies are esse...