BFRF1 protein is involved in EBV-mediated autophagy manipulation

• Published in: Microbes and infection Vol. 22; no. 10; pp. 585 - 591
• Main Authors: Gonnella, Roberta, Dimarco, Marzia, Farina, Giuseppina A., Santarelli, Roberta, Valia, Sandro, Faggioni, Alberto, Angeloni, Antonio, Cirone, Mara, Farina, Antonella
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.11.2020
• Subjects: Autophagy; BFRF1; EBV lytic cycle; HEK293 Cells; Herpesvirus 4, Human - physiology; Humans; Lamin B1; Lamin Type B - metabolism; LC3; Membrane Proteins - metabolism; Microtubule-Associated Proteins - metabolism; Nuclear egress; Nuclear Envelope - metabolism; Protein Binding; rab GTP-Binding Proteins - metabolism; rab7 GTP-Binding Proteins; Viral Proteins - metabolism; Virus Release; EBV lytic cycle; Lamin B1; BFRF1; Nuclear egress; Autophagy; LC3

Viral egress and autophagy are two mechanisms that seem to be strictly connected in Herpesviruses’s biology. Several data suggest that the autophagic machinery facilitates the egress of viral capsids and thus the production of new infectious particles. In the Herpesvirus family, viral nuclear egress...