Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane
In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 570...
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| Published in | Journal of materials science Vol. 41; no. 8; pp. 2423 - 2428 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Springer
01.04.2006
Springer Nature B.V |
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| Online Access | Get full text |
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| Abstract | In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 5701-F1 by freeze drying of a dioxane and water solution in combination with salt leaching. It was possible to obtain very porous scaffolds with a very high interconnectivity. Porosity, pore size and interconnectivity can be independently adjusted by varying the amount of water, porogen size and the amount of porogen used. The obtained compression moduli of the scaffolds were between 40 kPa and 400 kPa with a variation in porosity between 72 and 87%. These scaffolds are very suitable for the use as meniscus replacement materials. |
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| AbstractList | In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 5701-F1 by freeze drying of a dioxane and water solution in combination with salt leaching. It was possible to obtain very porous scaffolds with a very high interconnectivity. Porosity, pore size and interconnectivity can be independently adjusted by varying the amount of water, porogen size and the amount of porogen used. The obtained compression moduli of the scaffolds were between 40 kPa and 400 kPa with a variation in porosity between 72 and 87%. These scaffolds are very suitable for the use as meniscus replacement materials. |
| Author | VETH, R. P. H BUMA, P DE GROOT, J. H PENNINGS, A. J HEIJKANTS, R. G. J. C SCHOUTEN, A. J VAN TIENEN, T. G |
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| Keywords | Tissue engineering Use Mechanical properties Compressive strength Scaffold Experimental study Property processing relationship Porous material Freeze thaw cycle Structure processing relationship Morphology Polyurethane Biomaterial Manufacturing Porosity |
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| SubjectTerms | Applied sciences Biological and medical sciences Exact sciences and technology Forms of application and semi-finished materials Freeze drying Leaching Materials science Mechanical properties Medical sciences Miscellaneous Moisture content Polymer industry, paints, wood Polyurethane resins Pore size Porosity Porous materials Scaffolds Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Tissue engineering |
| Title | Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane |
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