A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves eicosapentaenoic and docosahexaenoic acid bioavailability in healthy adults

• Published in: European journal of nutrition Vol. 59; no. 6; pp. 2729 - 2737
• Main Authors: Bremmell, Kristen E., Briskey, David, Meola, Tahlia R., Mallard, Alistair, Prestidge, Clive A., Rao, Amanda
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer Nature B.V
• Subjects: absorption; Bioavailability; Chemistry; Chemistry and Materials Science; Docosahexaenoic acid; Drug delivery; drug delivery systems; Eicosapentaenoic acid; Emulsification; emulsifying; emulsions; Esters; Fatty acids; fish; Fish oils; High fat diet; high fat foods; Low fat diet; Nutrient deficiency; Nutrition; Omega-3 fatty acids; Original Contribution; Docosahexaenoic acid ethyl ester; Self-emulsifying delivery systems; Omega-3; Bioavailability; Eicosapentaenoic acid ethyl ester
• ISSN: 1436-6207; 1436-6215; 1436-6215
• DOI: 10.1007/s00394-019-02118-x

Purpose Application of intelligent formulation design has the ability to address the poor bioavailability and improve the fasted state bioavailability of fish oils. In this study we assessed the ability of a self-emulsifying drug delivery system (SEDDS), AquaCelle ® , as an additive to enhance the o...