Evaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease

• Published in: Pharmacological reports Vol. 69; no. 3; pp. 386 - 392
• Main Authors: Siczek, Krzysztof, Zatorski, Hubert, Chmielowiec-Korzeniowska, Anna, Kordek, Radzisław, Tymczyna, Leszek, Fichna, Jakub
• Format: Journal Article
• Language: English
• Published: Cham Elsevier B.V 01.06.2017; Springer International Publishing
• Subjects: Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Chemistry, Pharmaceutical - methods; Colitis - drug therapy; Colitis - pathology; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - pathology; Crohn Disease - drug therapy; Crohn Disease - pathology; Crohn’s disease; Dextran Sulfate - toxicity; Disease Models, Animal; Drug Safety and Pharmacovigilance; Inflammation - drug therapy; Inflammation - pathology; Inflammatory bowel disease; Male; Mice; Mice, Inbred BALB C; Microbiota; Original Article; Pharmacotherapy; Pharmacy; Silver - chemistry; Silver - pharmacology; Silver-coated glass beads; Trinitrobenzenesulfonic Acid - toxicity; Ulcerative colitis; Inflammatory bowel disease; Microbiota; Silver-coated glass beads; Crohn’s disease; Ulcerative colitis

Recent studies point at the anti-inflammatory action of silver through induction of apoptosis of inflammatory cells via oxidative stress, promotion of wound healing as well as antimicrobial effect. Our aim was to design a new formulation based on silver and validate its anti-inflammatory activity in...