Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism

• Published in: Gut microbes Vol. 17; no. 1; p. 2455506
• Main Authors: Fumagalli, Andrea, Castells-Nobau, Anna, Trivedi, Dakshat, Garre-Olmo, Josep, Puig, Josep, Ramos, Rafel, Ramió-Torrentà, Lluís, Pérez-Brocal, Vicente, Moya, Andrés, Swann, Jonathan, Martin-Garcia, Elena, Maldonado, Rafael, Fernández-Real, José Manuel, Mayneris-Perxachs, Jordi
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Aged; archaea; Archaea - classification; Archaea - genetics; Archaea - metabolism; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Bacteria - metabolism; Butyrates - metabolism; cognition; Cognition - physiology; cognitive flexibility; Cohort Studies; executive function; Female; Gastrointestinal Microbiome - physiology; Histidine - metabolism; Humans; Male; Metagenomics; Microbiota; Middle Aged; Research Paper; Microbiota; cognition; cognitive flexibility; archaea; executive function

The relationship between bacteria, cognitive function and obesity is well established, yet the role of archaeal species remains underexplored. We used shotgun metagenomics and neuropsychological tests to identify microbial species associated with cognition in a discovery cohort (IRONMET,  = 125). In...