Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

• Published in: Blood Vol. 122; no. 1; pp. 134 - 142
• Main Authors: Ajjan, Ramzi A., Gamlen, Toby, Standeven, Kristina F., Mughal, Salihah, Hess, Katharina, Smith, Kerrie A., Dunn, Emma J., Anwar, M. Maqsud, Rabbani, Naila, Thornalley, Paul J., Philippou, Helen, Grant, Peter J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.07.2013
• Subjects: Diabetes Mellitus, Type 1 - blood; Enzyme Activation - physiology; Fibrinogen - metabolism; Fibrinolysin - biosynthesis; Fibrinolysis - physiology; Glycosylation; Humans; Mucoproteins - metabolism; Plasminogen - genetics; Plasminogen - metabolism; Protein Binding - physiology; Protein Processing, Post-Translational - physiology; Thrombosis - blood
• ISSN: 0006-4971; 1528-0020; 1528-0020
• DOI: 10.1182/blood-2013-04-494641

Diabetes is associated with hypofibrinolysis by mechanisms that are only partially understood. We investigated the effects of in vivo plasminogen glycation on fibrinolysis, plasmin generation, protein proteolytic activity, and plasminogen-fibrin interactions. Plasma was collected from healthy contro...