Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies

• Published in: Clinical pharmacology and therapeutics Vol. 89; no. 1; p. 65
• Main Authors: Angiolillo, D J, Gibson, C M, Cheng, S, Ollier, C, Nicolas, O, Bergougnan, L, Perrin, L, LaCreta, F P, Hurbin, F, Dubar, M
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - administration & dosage; 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects; 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology; Adult; Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacology; Female; Half-Life; Humans; Male; Middle Aged; Omeprazole - administration & dosage; Omeprazole - adverse effects; Omeprazole - pharmacology; Platelet Activation - drug effects; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - blood; Platelet Aggregation Inhibitors - pharmacokinetics; Platelet Aggregation Inhibitors - pharmacology; Prodrugs - adverse effects; Prodrugs - pharmacokinetics; Prodrugs - pharmacology; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - pharmacology; Ticlopidine - analogs & derivatives; Ticlopidine - blood; Ticlopidine - pharmacokinetics; Ticlopidine - pharmacology; Young Adult

Four randomized, placebo-controlled, crossover studies were conducted among 282 healthy subjects to investigate whether an interaction exists between clopidogrel (300-mg loading dose/75-mg/day maintenance dose) and the proton-pump inhibitor (PPI) omeprazole (80 mg) when they are administered simulta...