Let‐7a promotes periodontal bone regeneration of bone marrow mesenchymal stem cell aggregates via the Fas/FasL‐autophagy pathway

• Published in: Journal of cellular and molecular medicine Vol. 27; no. 24; pp. 4056 - 4068
• Main Authors: Yang, Shiyao, Gao, Jing, Chen, Meng, Sun, Yuting, Qiao, Xin, Mao, Hongchen, Guo, Li, Yu, Yang, Yang, Deqin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2023; John Wiley and Sons Inc
• Subjects: Antibodies; Apoptosis; Autophagy; Biotechnology; BMMSCs; Bone growth; Bone marrow; Bone Marrow Cells - metabolism; Bone Regeneration - genetics; Cell Differentiation - genetics; Cell growth; Cells, Cultured; cell‐aggregates; Fas/FasL; FasL protein; Laboratory animals; Medical research; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; microRNA; MicroRNAs; Original; Osteogenesis; Osteogenesis - genetics; Penicillin; periodontal regeneration; Polymerase chain reaction; Reagents; Regeneration; Stem cell transplantation; Stem cells; Tissue engineering; Up-Regulation; BMMSCs; Fas/FasL; microRNA; periodontal regeneration; cell-aggregates

Periodontal bone regeneration using bone marrow mesenchymal stem cell (BMMSC) transplantation is a promising method; however, the method for osteogenic differentiation of BMMSCs needs to be improved. In this research, we sought to identify the roles of let‐7a in the osteogenesis of BMMSCs and to pro...