Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans

• Published in: Cellular microbiology Vol. 23; no. 10; pp. e13378 - n/a
• Main Authors: Mogavero, Selene, Sauer, Frank M., Brunke, Sascha, Allert, Stefanie, Schulz, Daniela, Wisgott, Stephanie, Jablonowski, Nadja, Elshafee, Osama, Krüger, Thomas, Kniemeyer, Olaf, Brakhage, Axel A., Naglik, Julian R., Dolk, Edward, Hube, Bernhard
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.10.2021
• Subjects: Candida albicans; candidalysin; Cell membranes; Cytology; Damage; Epithelial cells; Epithelium; Fungal Proteins - genetics; Fungi; Humans; Hyphae; hyphal formation; Localization; Morphology; Mucosa; Nanobodies; pathogenicity mechanisms; Peptides; Toxins; Transcription; Virulence; Yeast; Candida albicans; hyphal formation; pathogenicity mechanisms; virulence; candidalysin

The human pathogenic fungus Candida albicans is a frequent cause of mucosal infections. Although the ability to transition from the yeast to the hypha morphology is essential for virulence, hypha formation and host cell invasion per se are not sufficient for the induction of epithelial damage. Rathe...