Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy
. Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this study was to investigate the contribution of individual drugs in renal transplant patients. 147 adults (19–84 years) and 60 juveniles (3–18 year...
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Published in | Journal of clinical periodontology Vol. 25; no. 6; pp. 457 - 464 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.1998
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Subjects | |
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Abstract | . Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this study was to investigate the contribution of individual drugs in renal transplant patients. 147 adults (19–84 years) and 60 juveniles (3–18 years) were scored for DIGO and other clinical variables. Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded. 44% of adults and 27% of children had DIGO. All patients were receiving prednisolone. More adults than children were administered cyclosporin, the reverse was true of azathioprine (P0.01), Explanatory models were evaluated by stepwise ordinal polynomial logistic regression. Statistically significant explanation (P0.05) of DIGO was afforded by prednisolone, nifedipine and azathioprine concentrations in adults and by cyclosporin, nifedipine and azathioprine concentrations in juveniles. Prednisolone and azathioprine were inversely related to the degree of DIGO. Plaque and irregularity scores, lip coverage and mouthbreathing status showed significant additional explanation in adults, replacing nifedipine and azathioprine in the final model. Irregularity was additionally explanatory in children, but no other clinical variables. A larger proportion of the variance of DIGO was explained by the available variables in children than in adults (pseudo r2=0.50 versus 0.25). The degree of DIGO in renal transplant patients is influenced by the dosage of a number of individual components of multiple drug therapy independently of the presence of local clinical factors. |
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AbstractList | Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this study was to investigate the contribution of individual drugs in renal transplant patients. 147 adults (19–84 years) and 60 juveniles (3–18 years) were scored for DIGO and other clinical variables. Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded. 44% of adults and 27% of children had DIGO. All patients were receiving prednisolone. More adults than children were administered cyclosporin, the reverse was true of azathioprine (
P
0.01), Explanatory models were evaluated by stepwise ordinal polynomial logistic regression. Statistically significant explanation (
P
0.05) of DIGO was afforded by prednisolone, nifedipine and azathioprine concentrations in adults and by cyclosporin, nifedipine and azathioprine concentrations in juveniles. Prednisolone and azathioprine were
inversely
related to the degree of DIGO. Plaque and irregularity scores, lip coverage and mouthbreathing status showed significant additional explanation in adults, replacing nifedipine and azathioprine in the final model. Irregularity was additionally explanatory in children, but no other clinical variables. A larger proportion of the variance of DIGO was explained by the available variables in children than in adults (pseudo
r
2
=0.50 versus 0.25). The degree of DIGO in renal transplant patients is influenced by the dosage of a number of individual components of multiple drug therapy independently of the presence of local clinical factors. Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug-induced gingival overgrowth (DIGO). The aim of this study was to investigate the contribution of individual drugs in renal transplant patients. 147 adults (19-84 years) and 60 juveniles (3-18 years) were scored for DIGO and other clinical variables. Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded. 44% of adults and 27% of children had DIGO. All patients were receiving prednisolone. More adults than children were administered cyclosporin, the reverse was true of azathioprine (p<0.01). Explanatory models were evaluated by stepwise ordinal polynomial logistic regression. Statistically significant explanation (p<0.05) of DIGO was afforded by prednisolone, nifedipine and azathioprine concentrations in adults and by cyclosporin, nifedipine and azathioprine concentrations in juveniles. Prednisolone and azathioprine were inversely related to the degree of DIGO. Plaque and irregularity scores, lip coverage and mouthbreathing status showed significant additional explanation in adults, replacing nifedipine and azathioprine in the final model. Irregularity was additionally explanatory in children, but no other clinical variables. A larger proportion of the variance of DIGO was explained by the available variables in children than in adults (pseudo r2=0.50 versus 0.25). The degree of DIGO in renal transplant patients is influenced by the dosage of a number of individual components of multiple drug therapy independently of the presence of local clinical factors. . Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this study was to investigate the contribution of individual drugs in renal transplant patients. 147 adults (19–84 years) and 60 juveniles (3–18 years) were scored for DIGO and other clinical variables. Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded. 44% of adults and 27% of children had DIGO. All patients were receiving prednisolone. More adults than children were administered cyclosporin, the reverse was true of azathioprine (P0.01), Explanatory models were evaluated by stepwise ordinal polynomial logistic regression. Statistically significant explanation (P0.05) of DIGO was afforded by prednisolone, nifedipine and azathioprine concentrations in adults and by cyclosporin, nifedipine and azathioprine concentrations in juveniles. Prednisolone and azathioprine were inversely related to the degree of DIGO. Plaque and irregularity scores, lip coverage and mouthbreathing status showed significant additional explanation in adults, replacing nifedipine and azathioprine in the final model. Irregularity was additionally explanatory in children, but no other clinical variables. A larger proportion of the variance of DIGO was explained by the available variables in children than in adults (pseudo r2=0.50 versus 0.25). The degree of DIGO in renal transplant patients is influenced by the dosage of a number of individual components of multiple drug therapy independently of the presence of local clinical factors. |
Author | Wilson, R. F. Ogg, C. S. Morel, A. Rigden, S. P. A. Ashley, F. P. Koffman, C. G. Smith, D. |
Author_xml | – sequence: 1 givenname: R. F. surname: Wilson fullname: Wilson, R. F. organization: Department of Dental Clinical Research, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 2 givenname: A. surname: Morel fullname: Morel, A. organization: Department of Periodontology and Preventive Dentistry, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 3 givenname: D. surname: Smith fullname: Smith, D. organization: Department of Periodontology and Preventive Dentistry, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 4 givenname: C. G. surname: Koffman fullname: Koffman, C. G. organization: Department of Nephrology and Transplantation, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 5 givenname: C. S. surname: Ogg fullname: Ogg, C. S. organization: Department of Nephrology and Transplantation, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 6 givenname: S. P. A. surname: Rigden fullname: Rigden, S. P. A. organization: Paediatric Nephrology, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England – sequence: 7 givenname: F. P. surname: Ashley fullname: Ashley, F. P. organization: Department of Periodontology and Preventive Dentistry, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, London, England |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9667479$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1111/j.1600-051X.1996.tb00625.x 10.1016/0030-4220(86)90291-4 10.1902/jop.1994.65.8.744 10.1902/jop.1991.62.1.30 10.1111/j.1600-051X.1987.tb01524.x 10.1016/0030-4220(87)90007-7 10.1111/j.1600-0714.1989.tb00771.x 10.1902/jop.1987.58.9.639 10.1007/BF00865474 10.1902/jop.1984.55.12.708 10.1016/S0140-6736(87)91094-4 10.1016/0030-4220(83)90327-4 10.1902/jop.1978.49.6.307 10.1136/bmj.295.6593.310 10.1038/sj.bdj.4805474 10.1111/j.1600-051X.1983.tb01272.x 10.1902/jop.1994.65.7.671 10.1111/j.1600-051X.1996.tb00603.x 10.1097/00007890-199457120-00022 10.1111/j.1600-051X.1993.tb00360.x 10.4135/9781412984744 10.1111/j.1600-051X.1991.tb01698.x 10.1111/j.1600-051X.1996.tb02072.x 10.1111/j.1600-051X.1992.tb01140.x 10.1111/j.1600-0714.1991.tb00419.x 10.1902/jop.1986.57.5.294 10.1038/sj.bdj.4807564 10.1111/j.1600-051X.1993.tb01757.x 10.1902/jop.1987.58.11.752 10.1056/NEJM198107303050507 10.1111/j.1600-051X.1996.tb00586.x 10.1111/j.1600-051X.1992.tb00650.x 10.1177/10454411910020010201 |
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References | Brown, R. S., Beaver, W. T. & Bottomley, W. K. (1991) On the mechanism of drug- induced gingival hyperplasia. Journal of Oral Pathology & Medicine 20, 201-209. Daley, T. D. & Wysocki, G. P. (1984) Cyclosporine therapy. Its significance to the periodontist. Journal of Periodontology 55, 708-712. Hefti, A. F., Eshenaur, A. E., Hassell, T. M. & Stone, C. (1994) Gingival overgrowth in cyclosporin A treated multiple sclerosis patients. Journal of Periodontology 65, 744-749. Menard, S. W (1995) Applied logistic regression analysis. California : Sage Press. Barak, S., Engelberg, I. S. & Hiss, J. (1987) Gingival hyperplasia caused by nifedipine - histopathologic findings. Journal of Periodontology 58, 639-642. Barclay, S., Thomason, J. M., Idle, J. R. & Seymour, R. A. (1992) The incidence and severity of nifedipine-induced gingival overgrowth. Journal of Clinical Periodontology 19, 311-314. Thomason, J. M., Seymour, R. A., Ellis, J. S., Kelly, P. J., Parry, G., Dark, J., Wilkinson, R. & Ilde, J. R. (1996) Determinants of gingival overgrowth severity in organ transplant patients. Journal of Clinical Periodontology 23, 628-635. Pernu, H. E., Pernu, L. M., Knuuttila, M. L., Huttunen, K. R. (1993) Gingival overgrowth among renal transplant receipients and uraemic patients. Nephrology, Dialysis, Transplantation 8, 1254-1258. Montebugnoli, L., Bernardi, F. & Magelli, C.M Cyclosporin-a-induced gingival overgrowth in heart transplant patients. Journal of Clinical Periodontology 23, 868-872. Daley, T. D., Wysocki, G. P & Day, C. (1986) Clinical and pharmacologic correlations in cyclosporine-induced gingival hyperplasia. Oral Surgery, Oral Medicine, Oral Pathology 62, 417-421. Cebeci, I., Kantarci, A., Firatli, E., Aygun, S., Tanyeri, H., Aydin, A. E., Carin, M., Guc, U., & Tuncer, O. (1996) Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. Journal of Clinical Periodontology 23, 737-742. Ross, P. J., Nazif, M. M., Zullo, T., Sitelli, B. & Guevara, P (1989) Effects of cyclosporine A on gingival status following liver transplantation. Journal of Dentistry for Children 56, 56-59. McGaw, T., Lam, S. & Coates, J. (1988) Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surgery, Oral Medicine, Oral Pathology 64, 293-297. Somacarrera, M. L., Hernandez, G., Acero, J. & Moskow, B. S. (1994) Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. Journal of Periodontology 65, 671-675. Thomason, J. M., Seymour, R. A. & Rice, N. (1993) The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. Journal of Clinical Periodontology 20, 37-40. Seymour, R. A., Thomason, J. M. & Ellis, J. S. (1996) The pathogenesis of drug-induced gingival overgrowth. Journal of Clinical Periodontology 23, 165-175. Seymour, R. A., Jacobs, D. J. (1992) Cyclosporin and the gingival tissues. Journal of Clinical Periodontology 19, 1-11. King, G. N., Fullinfaw, R., Higgins, T. J., Walker, R. G., Francis, D. M. & Wiesenfeld, D. (1993) Gingival hyperplasia in renal allograft recipients receiving cyclosporine A and calcium antagonists. Journal of Clinical Periodontology 20, 286-293. Bokenkamp, A., Bohnhorst, B., Beier, C., Albers, N., Offner, G. & Brodehl, J. (1994) Nifiedipine aggravates cyclosporine A-induced gingival hyperplasia. Pediatriatric Nephrology 8, 181-185. Nishikawa, S., Tada, H., Hamasaki, A., Kido, J., Nagata, T., Ishida, H., Wakano, Y. (1991) Nifedipin-induced gingival hyperplasia: a clinical and in vitro study. Journal of Periodontology 62, 30-35. Starzl, T. E., Klintmalm, G. B., Porter, K. A., Iwatsuki, S. & Schroter, G. P (1981) Liver transplantation with use of cyclosporine and prednisone. New England Journal of Medicine 395, 266-269. Hassell, T. M. & Hefti, A. F (1991) Drug-induced gingival overgrowth: old problem, new problem. Critical Reviews in Oral Biology & Medicine 2, 103-147. Kardachi, B. J. & Newcomb, G. M. (1978) A clinical study of gingival inflammation in renal transplant recipients taking immunosuppressive drugs. Journal of Periodontology 49, 307-309. Aldrich, J. H. & Nelson, F. D. (1984) Linear probability, logit, and probit módels. California : Sage Press. Pernu, H. E., Knuuttila, M. L. E. (1994) Drug-induced gingival overgrowth and class II major histocompatability antigens. Transplantation 57, 1811-1813. Seibel, W., Yahia, N. A., McCleary, L. B., Lesko, L. J. & Hassell, T. M. (1989) Cyclosporine- induced gingival overgrowth in beagle dogs. Journal of Oral Pathology & Medicine 18, 240-245. Feehally, J., Walls, J., Mistry, N., Horsburgh, T., Taylor, J., Veitch, P. S. & Bell, P. R.M (1987) Does nifedipine ameliorate cyclosporine A nephrotoxicity British Medical Journal 295, 310. Seymour, R. A., Thomason, J. M. & Ellis, J. S. (1994) Oral and dental problems in the organ transplant patient. Dental Update 21, 209-212. Lundergan, W. P. (1989) Drug-induced gingival enlargements. Journal of the Canadian Dental Association 17, 48-52. Seymour, R. A., Smith, D. G. & Rogers, S. R. (1987) The comparative effect of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. Journal of Clinical Periodontology 14, 610-613. Wysocki, G. P., Gretzinger, H. A., Laupacis, A., Ulan, R. A. & Stiller, C. R. (1983) Fibrous hyperplasia of the gingiva: a side effect of cyclosporin A therapy. Oral Surgery, Oral Medicine, Oral Pathology 55, 274-278. Rateitschak-Plüss, E.M., Hefti, A., Lörtscher, R. & Thiel, G. (1983) Initial observation that cyclosporin A induces gingival enlargement in man. Journal of Clinical Periodontology 10, 237-246. Tyldesley, W. R. & Rotter, E. (1984) Gingival hyperplasia induced by cyclosporin A. British Dental Journal 157, 305-309. Seymour, R. A. (1991) Calcium channel blockers and gingival overgrowth. British Dental Journal 170, 376-379. Seymour, R. A., Smith, D. G. (1991) The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes. Journal of Clinical Periodontology 18, 107-110. Addy, M., Dummer, P. M. H., Hunter, M. L., Kingdom, A. & Shaw, W. C. (1987) A study of the association of fraenal attachment, lip coverage and vestibular depth with plaque and gingivitis. Journal of Periodontology 58, 752-757. Slavin, J., Taylor, J. (1987) Cyclosporin, nifedipine and gingival hyperplasia. Lancet 320, 739. Rostock, M. H., Fry, H. R. & Turner, J. E. (1986) Severe gingival overgrowth associated with cyclosporine therapy. Journal of Periodontology 57, 294-299. 1987; 58 23 1993; 8 1987; 14 1991; 2 1991; 18 1987; 320 1986; 57 1993; 20 1991; 170 1983; 10 1992; 19 1995 1994; 65 1994; 21 1983; 55 1987; 295 1994; 8 1989; 56 1986; 62 1984; 157 1981; 395 1991; 20 1984; 55 1991; 62 1984 1994; 57 1978; 49 1988; 64 1996; 23 1989; 17 1989; 18 Lundergan W. P. (e_1_2_1_16_1) 1989; 17 e_1_2_1_20_1 Montebugnoli L. (e_1_2_1_19_1); 23 e_1_2_1_23_1 Ross P. J. (e_1_2_1_24_1) 1989; 56 Pernu H. E. (e_1_2_1_22_1) 1993; 8 e_1_2_1_21_1 Menard S. W (e_1_2_1_18_1) 1995 e_1_2_1_27_1 e_1_2_1_28_1 e_1_2_1_25_1 e_1_2_1_26_1 e_1_2_1_29_1 Seymour R. A. (e_1_2_1_31_1) 1994; 21 e_1_2_1_7_1 e_1_2_1_8_1 e_1_2_1_30_1 e_1_2_1_5_1 e_1_2_1_6_1 e_1_2_1_3_1 e_1_2_1_12_1 e_1_2_1_35_1 e_1_2_1_4_1 e_1_2_1_13_1 e_1_2_1_34_1 e_1_2_1_10_1 e_1_2_1_33_1 e_1_2_1_2_1 e_1_2_1_11_1 e_1_2_1_32_1 e_1_2_1_39_1 e_1_2_1_17_1 e_1_2_1_38_1 e_1_2_1_14_1 e_1_2_1_37_1 e_1_2_1_15_1 e_1_2_1_36_1 e_1_2_1_9_1 |
References_xml | – volume: 62 start-page: 30 year: 1991 end-page: 35 article-title: Nifedipin‐induced gingival hyperplasia: a clinical and in vitro study publication-title: Journal of Periodontology – volume: 62 start-page: 417 year: 1986 end-page: 421 article-title: Clinical and pharmacologic correlations in cyclosporine‐induced gingival hyperplasia publication-title: Oral Surgery, Oral Medicine, Oral Pathology – volume: 55 start-page: 708 year: 1984 end-page: 712 article-title: Cyclosporine therapy. Its significance to the periodontist publication-title: Journal of Periodontology – volume: 57 start-page: 1811 year: 1994 end-page: 1813 article-title: Drug‐induced gingival overgrowth and class II major histocompatability antigens publication-title: Transplantation – volume: 170 start-page: 376 year: 1991 end-page: 379 article-title: Calcium channel blockers and gingival overgrowth publication-title: British Dental Journal – volume: 295 start-page: 310 year: 1987 article-title: Does nifedipine ameliorate cyclosporine A nephrotoxicity publication-title: British Medical Journal – volume: 2 start-page: 103 year: 1991 end-page: 147 article-title: Drug‐induced gingival overgrowth: old problem, new problem publication-title: Critical Reviews in Oral Biology & Medicine – volume: 8 start-page: 1254 year: 1993 end-page: 1258 article-title: Gingival overgrowth among renal transplant receipients and uraemic patients publication-title: Nephrology, Dialysis, Transplantation – volume: 14 start-page: 610 year: 1987 end-page: 613 article-title: The comparative effect of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients publication-title: Journal of Clinical Periodontology – volume: 17 start-page: 48 year: 1989 end-page: 52 article-title: Drug‐induced gingival enlargements publication-title: Journal of the Canadian Dental Association – volume: 20 start-page: 286 year: 1993 end-page: 293 article-title: Gingival hyperplasia in renal allograft recipients receiving cyclosporine A and calcium antagonists publication-title: Journal of Clinical Periodontology – volume: 65 start-page: 671 year: 1994 end-page: 675 article-title: Factors related to the incidence and severity of cyclosporin‐induced gingival overgrowth in transplant patients. A longitudinal study publication-title: Journal of Periodontology – volume: 58 start-page: 752 year: 1987 end-page: 757 article-title: A study of the association of fraenal attachment, lip coverage and vestibular depth with plaque and gingivitis publication-title: Journal of Periodontology – volume: 8 start-page: 181 year: 1994 end-page: 185 article-title: Nifiedipine aggravates cyclosporine A‐induced gingival hyperplasia publication-title: Pediatriatric Nephrology – volume: 19 start-page: 311 year: 1992 end-page: 314 article-title: The incidence and severity of nifedipine‐induced gingival overgrowth publication-title: Journal of Clinical Periodontology – volume: 157 start-page: 305 year: 1984 end-page: 309 article-title: Gingival hyperplasia induced by cyclosporin A publication-title: British Dental Journal – volume: 64 start-page: 293 year: 1988 end-page: 297 article-title: Cyclosporin‐induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva publication-title: Oral Surgery, Oral Medicine, Oral Pathology – volume: 58 start-page: 639 year: 1987 end-page: 642 article-title: Gingival hyperplasia caused by nifedipine – histopathologic findings publication-title: Journal of Periodontology – volume: 21 start-page: 209 year: 1994 end-page: 212 article-title: Oral and dental problems in the organ transplant patient publication-title: Dental Update – volume: 18 start-page: 107 year: 1991 end-page: 110 article-title: The effect of a plaque control programme on the incidence and severity of cyclosporin‐induced gingival changes publication-title: Journal of Clinical Periodontology – year: 1984 – volume: 23 start-page: 737 year: 1996 end-page: 742 article-title: Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine‐A publication-title: Journal of Clinical Periodontology – volume: 395 start-page: 266 year: 1981 end-page: 269 article-title: Liver transplantation with use of cyclosporine and prednisone publication-title: New England Journal of Medicine – volume: 49 start-page: 307 year: 1978 end-page: 309 article-title: A clinical study of gingival inflammation in renal transplant recipients taking immunosuppressive drugs publication-title: Journal of Periodontology – volume: 55 start-page: 274 year: 1983 end-page: 278 article-title: Fibrous hyperplasia of the gingiva: a side effect of cyclosporin A therapy publication-title: Oral Surgery, Oral Medicine, Oral Pathology – volume: 65 start-page: 744 year: 1994 end-page: 749 article-title: Gingival overgrowth in cyclosporin A treated multiple sclerosis patients publication-title: Journal of Periodontology – volume: 10 start-page: 237 year: 1983 end-page: 246 article-title: Initial observation that cyclosporin A induces gingival enlargement in man publication-title: Journal of Clinical Periodontology – volume: 20 start-page: 37 year: 1993 end-page: 40 article-title: The prevalence and severity of cyclosporin and nifedipine‐induced gingival overgrowth publication-title: Journal of Clinical Periodontology – volume: 19 start-page: 1 year: 1992 end-page: 11 article-title: Cyclosporin and the gingival tissues publication-title: Journal of Clinical Periodontology – volume: 23 start-page: 165 year: 1996 end-page: 175 article-title: The pathogenesis of drug‐induced gingival overgrowth publication-title: Journal of Clinical Periodontology – volume: 20 start-page: 201 year: 1991 end-page: 209 article-title: On the mechanism of drug‐ induced gingival hyperplasia publication-title: Journal of Oral Pathology & Medicine – year: 1995 – volume: 23 start-page: 868 end-page: 872 article-title: Cyclosporin‐a‐induced gingival overgrowth in heart transplant patients publication-title: Journal of Clinical Periodontology – volume: 57 start-page: 294 year: 1986 end-page: 299 article-title: Severe gingival overgrowth associated with cyclosporine therapy publication-title: Journal of Periodontology – volume: 23 start-page: 628 year: 1996 end-page: 635 article-title: Determinants of gingival overgrowth severity in organ transplant patients publication-title: Journal of Clinical Periodontology – volume: 56 start-page: 56 year: 1989 end-page: 59 article-title: Effects of cyclosporine A on gingival status following liver transplantation publication-title: Journal of Dentistry for Children – volume: 18 start-page: 240 year: 1989 end-page: 245 article-title: Cyclosporine‐ induced gingival overgrowth in beagle dogs publication-title: Journal of Oral Pathology & Medicine – volume: 320 start-page: 739 year: 1987 article-title: Cyclosporin, nifedipine and gingival hyperplasia publication-title: Lancet – volume: 23 start-page: 868 ident: e_1_2_1_19_1 article-title: Cyclosporin‐a‐induced gingival overgrowth in heart transplant patients publication-title: Journal of Clinical Periodontology doi: 10.1111/j.1600-051X.1996.tb00625.x contributor: fullname: Montebugnoli L. – ident: e_1_2_1_10_1 doi: 10.1016/0030-4220(86)90291-4 – ident: e_1_2_1_13_1 doi: 10.1902/jop.1994.65.8.744 – ident: e_1_2_1_20_1 doi: 10.1902/jop.1991.62.1.30 – ident: e_1_2_1_30_1 doi: 10.1111/j.1600-051X.1987.tb01524.x – ident: e_1_2_1_17_1 doi: 10.1016/0030-4220(87)90007-7 – ident: e_1_2_1_26_1 doi: 10.1111/j.1600-0714.1989.tb00771.x – volume: 17 start-page: 48 year: 1989 ident: e_1_2_1_16_1 article-title: Drug‐induced gingival enlargements publication-title: Journal of the Canadian Dental Association contributor: fullname: Lundergan W. P. – ident: e_1_2_1_4_1 doi: 10.1902/jop.1987.58.9.639 – ident: e_1_2_1_6_1 doi: 10.1007/BF00865474 – ident: e_1_2_1_9_1 doi: 10.1902/jop.1984.55.12.708 – ident: e_1_2_1_33_1 doi: 10.1016/S0140-6736(87)91094-4 – ident: e_1_2_1_39_1 doi: 10.1016/0030-4220(83)90327-4 – ident: e_1_2_1_14_1 doi: 10.1902/jop.1978.49.6.307 – ident: e_1_2_1_11_1 doi: 10.1136/bmj.295.6593.310 – ident: e_1_2_1_38_1 doi: 10.1038/sj.bdj.4805474 – ident: e_1_2_1_23_1 doi: 10.1111/j.1600-051X.1983.tb01272.x – ident: e_1_2_1_34_1 doi: 10.1902/jop.1994.65.7.671 – ident: e_1_2_1_8_1 doi: 10.1111/j.1600-051X.1996.tb00603.x – ident: e_1_2_1_21_1 doi: 10.1097/00007890-199457120-00022 – ident: e_1_2_1_15_1 doi: 10.1111/j.1600-051X.1993.tb00360.x – ident: e_1_2_1_3_1 doi: 10.4135/9781412984744 – ident: e_1_2_1_28_1 doi: 10.1111/j.1600-051X.1991.tb01698.x – volume: 21 start-page: 209 year: 1994 ident: e_1_2_1_31_1 article-title: Oral and dental problems in the organ transplant patient publication-title: Dental Update contributor: fullname: Seymour R. A. – ident: e_1_2_1_32_1 doi: 10.1111/j.1600-051X.1996.tb02072.x – ident: e_1_2_1_29_1 doi: 10.1111/j.1600-051X.1992.tb01140.x – ident: e_1_2_1_7_1 doi: 10.1111/j.1600-0714.1991.tb00419.x – ident: e_1_2_1_25_1 doi: 10.1902/jop.1986.57.5.294 – volume-title: Applied logistic regression analysis year: 1995 ident: e_1_2_1_18_1 contributor: fullname: Menard S. W – ident: e_1_2_1_27_1 doi: 10.1038/sj.bdj.4807564 – ident: e_1_2_1_36_1 doi: 10.1111/j.1600-051X.1993.tb01757.x – ident: e_1_2_1_2_1 doi: 10.1902/jop.1987.58.11.752 – ident: e_1_2_1_35_1 doi: 10.1056/NEJM198107303050507 – ident: e_1_2_1_37_1 doi: 10.1111/j.1600-051X.1996.tb00586.x – volume: 56 start-page: 56 year: 1989 ident: e_1_2_1_24_1 article-title: Effects of cyclosporine A on gingival status following liver transplantation publication-title: Journal of Dentistry for Children contributor: fullname: Ross P. J. – ident: e_1_2_1_5_1 doi: 10.1111/j.1600-051X.1992.tb00650.x – ident: e_1_2_1_12_1 doi: 10.1177/10454411910020010201 – volume: 8 start-page: 1254 year: 1993 ident: e_1_2_1_22_1 article-title: Gingival overgrowth among renal transplant receipients and uraemic patients publication-title: Nephrology, Dialysis, Transplantation contributor: fullname: Pernu H. E. |
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Snippet | . Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this... Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug-induced gingival overgrowth (DIGO). The aim of this study... Drug regimens for transplantation often consist of multiple therapeutic agents and may result in drug‐induced gingival overgrowth (DIGO). The aim of this study... |
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SubjectTerms | Adolescent Adult Age Factors Aged Aged, 80 and over Analysis of Variance azathioprine Azathioprine - administration & dosage Azathioprine - adverse effects Body Weight Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - adverse effects Child Child, Preschool Cyclosporine - administration & dosage Cyclosporine - adverse effects Cyclosporine - blood cyclosporins Dental Plaque - complications Drug Combinations Female gingival overgrowth Gingival Overgrowth - chemically induced Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - blood kidney Kidney Transplantation - adverse effects Lip - physiopathology Logistic Models Male Middle Aged Mouth Breathing - complications Mouth Breathing - physiopathology nifedipine Nifedipine - administration & dosage Nifedipine - adverse effects prednisolone Prednisolone - administration & dosage Prednisolone - adverse effects Time Factors transplantation |
Title | Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy |
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