Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high‐molecular‐weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6...

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Published inJournal of cellular and molecular medicine Vol. 27; no. 17; pp. 2594 - 2602
Main Authors Hua, Chun‐Hung, Chuang, Chun‐Yi, Chien, Yi‐Chung, Su, Chun‐Wen, Chen, Shuo‐Chueh, Liu, Liang‐Chih, Yang, Shun‐Fa, Yu, Yung‐Luen
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.09.2023
John Wiley and Sons Inc
Subjects
Alcohol
Alcohol abuse
Carcinogens
Drug abuse
Genetic diversity
Glycoproteins
Head & neck cancer
Head and neck carcinoma
Liver cancer
lymph node metastasis
Lymph nodes
Medical prognosis
Metastases
Metastasis
MUC6
Mucin
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Original
Phenotypes
Regression analysis
Single-nucleotide polymorphism
single‐nucleotide polymorphisms
Smoking
Software
Squamous cell carcinoma
Taiwan
oral squamous cell carcinoma
single-nucleotide polymorphisms
MUC6
lymph node metastasis
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Abstract Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high‐molecular‐weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease‐free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single‐nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real‐time PCR. After adjusting for other co‐variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild‐type carriers among non‐betel‐quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.
AbstractList Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high-molecular-weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease-free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single-nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real-time PCR. After adjusting for other co-variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild-type carriers among non-betel-quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high-molecular-weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease-free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single-nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real-time PCR. After adjusting for other co-variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild-type carriers among non-betel-quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.
Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high-molecular-weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease-free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single-nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real-time PCR. After adjusting for other co-variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild-type carriers among non-betel-quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.
Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high‐molecular‐weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease‐free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single‐nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real‐time PCR. After adjusting for other co‐variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild‐type carriers among non‐betel‐quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.
Author Chuang, Chun‐Yi
Hua, Chun‐Hung
Yang, Shun‐Fa
Su, Chun‐Wen
Yu, Yung‐Luen
Chien, Yi‐Chung
Chen, Shuo‐Chueh
Liu, Liang‐Chih
AuthorAffiliation 7 Institute of Medicine Chung Shan Medical University Taichung Taiwan
4 Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan
10 School of Medicine, College of Medicine China Medical University Taichung Taiwan
8 Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan
9 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine China Medical University Hospital Taichung Taiwan
5 Institute of Translational Medicine and New Drug Development China Medical University Taichung Taiwan
6 Center for Molecular Medicine China Medical University Hospital Taichung Taiwan
3 Department of Otolaryngology Chung Shan Medical University Hospital Taichung Taiwan
1 Department of Otorhinolaryngology Head and Neck Surgery China Medical University Hospital Taichung Taiwan
11 Department of Surgery China Medical University Hospital Taichung Taiwan
12 Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan
2
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Keywords oral squamous cell carcinoma
single-nucleotide polymorphisms
MUC6
lymph node metastasis
Language English
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Notes Chun‐Hung Hua and Chun‐Yi Chuang contributed equally to this work.
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Snippet Head and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are...
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SubjectTerms Alcohol
Alcohol abuse
Carcinogens
Drug abuse
Genetic diversity
Glycoproteins
Head & neck cancer
Head and neck carcinoma
Liver cancer
lymph node metastasis
Lymph nodes
Medical prognosis
Metastases
Metastasis
MUC6
Mucin
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Original
Phenotypes
Regression analysis
Single-nucleotide polymorphism
single‐nucleotide polymorphisms
Smoking
Software
Squamous cell carcinoma
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Title Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma
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Volume 27
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