Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response

• Published in: Aging cell Vol. 23; no. 5; pp. e14126 - n/a
• Main Authors: Linden, Janette, Stefens, Sanne J. M., Heredia‐Genestar, José María, Ridwan, Yanto, Brandt, Renata M. C., Vliet, Nicole, Beer, Isa, Thiel, Bibi S., Steen, Herman, Cheng, Caroline, Roks, Anton J. M., Danser, A. H. Jan, Essers, Jeroen, Pluijm, Ingrid
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2024; John Wiley and Sons Inc
• Subjects: Aging; Aging - metabolism; Alcohol; Animals; Cardiovascular disease; Cardiovascular diseases; Cardiovascular system; Coronary vessels; DNA damage; DNA Repair; DNA-Binding Proteins - deficiency; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Elastin; Endonucleases - deficiency; Endonucleases - genetics; Endonucleases - metabolism; Endothelium; Ercc1; ERCC1 protein; Ethanol; Extracellular matrix; Extracellular Matrix - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle contraction; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Phenotype; Phenotypes; Proteins; Proteoglycans; Senescence; Smooth muscle; Structure-function relationships; vascular remodeling; United States > US; aging; cardiovascular diseases; vascular remodeling; Ercc1

Cardiovascular diseases are the number one cause of death globally. The most important determinant of cardiovascular health is a person's age. Aging results in structural changes and functional decline of the cardiovascular system. DNA damage is an important contributor to the aging process, an...