Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology - Suárez-Calvet, Marc; Morenas-Rodríguez, Estrella; Kleinberger, Gernot; Schlepckow, Kai; Araque Caballero, Miguel Ángel; Franzmeier, Nicolai; Capell, Anja; Fellerer, Katrin; Nuscher, Brigitte; Eren, Erden; Levin, Johannes; Deming, Yuetiva; et al. (Molecular neurodegeneration, 2019)
Keywords: Aged; Aged, 80 and over; Aging; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyotrophic lateral sclerosis; Biomarkers; Biomarkers - cerebrospinal fluid; Central nervous system; Cerebrospinal fluid; Cross-Sectional Studies; Dementia; Dementia disorders; Disease; Enzyme-linked immunosorbent assay; Female; Fluids; Gene expression; Genetic diversity; Humans; Male; Membrane Glycoproteins - cerebrospinal fluid; Membrane Glycoproteins - genetics; Microglia; Middle Aged; Mutation; Nerve Degeneration - pathology; Nervous system; Neurodegeneration; Neuroinflammation; Pathology; Plasma; Receptors, Immunologic - genetics; Shedding; Tau protein; tau Proteins - cerebrospinal fluid; β-Amyloid; Shedding; Alzheimer’s disease; Neurodegeneration; Biomarkers; Neuroinflammation; TREM2; Microglia