Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

• Published in: Journal of hematology and oncology Vol. 12; no. 1; pp. 12 - 14
• Main Authors: Jan, Yi-Hua, Lai, Tsung-Ching, Yang, Chih-Jen, Lin, Yuan-Feng, Huang, Ming-Shyan, Hsiao, Michael
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.01.2019; BMC
• Subjects: A549 Cells; Acetylcysteine; Adenocarcinoma; Adenocarcinoma of Lung - drug therapy; Adenocarcinoma of Lung - metabolism; Adenocarcinoma of Lung - pathology; Adenylate kinase; Adenylate Kinase - antagonists & inhibitors; Adenylate Kinase - genetics; Adenylate Kinase - metabolism; AK4; Animal models; Animals; Antioxidants; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Drug development; EMT; Epithelial-Mesenchymal Transition - genetics; Follow-Up Studies; Gene expression; Gene Knockdown Techniques; Hematology; HIF-1α; Histology; Homeostasis; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunohistochemistry; Kinases; Liver Neoplasms - secondary; Lung cancer; Lung cancer metastasis; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Melanoma; Mesenchyme; Metabolism; Metastases; Metastasis; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness - genetics; Oncology; Oxidative Stress; Pharmacogenomics; Protein expression; Proteins; Reactive Oxygen Species - metabolism; ROS; Transcription factors; Transfection; Tumor Hypoxia; Withaferin-A; Withanolides - pharmacology; Xenograft Model Antitumor Assays; Xenografts; United States > US; Lung cancer metastasis; AK4; HIF-1α; EMT; Withaferin-A; ROS

Adenylate kinase 4 (AK4) has been identified as a biomarker of metastasis in lung cancer. However, the impacts of AK4 on metabolic genes and its translational value for drug repositioning remain unclear. Ingenuity upstream analyses were used to identify potential transcription factors that regulate...