Genetic Concordance of Staphylococcus aureus From Oropharyngeal and Sputum Cultures in People With Cystic Fibrosis

• Published in: Pediatric pulmonology Vol. 60; no. 1; pp. e27475 - n/a
• Main Authors: Zirbes, Christian F., Feder, Andries, Pamatmat, Anthony J., Bartels, Alyssa R., Pitcher, Nicholas J., Rozen, Alexis L., Teresi, Mary, Krogh, Justin, Regan, Margaret, Arnold, Erin A., Hill, Jared J., Reinhardt, Lindsey D., Oberto, Carlos L., Boyken, Linda, Reeb, Valérie C., Moustafa, Ahmed M., Planet, Paul J., Fischer, Anthony J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2025; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Child; Child, Preschool; Cystic fibrosis; Cystic Fibrosis - microbiology; Female; Genomes; Humans; Male; Original; oropharynx; Oropharynx - microbiology; Phylogeny; Polymorphism, Single Nucleotide; Prospective Studies; sputum; Sputum - microbiology; Staphylococcal Infections - diagnosis; Staphylococcal Infections - microbiology; Staphylococcus Aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - isolation & purification; strain; throat swab; Whole Genome Sequencing; Young Adult; strain; whole genome sequencing; Staphylococcus Aureus; sputum; throat swab; oropharynx

ABSTRACT Background People with cystic fibrosis (CF) may not expectorate sputum at young ages or after they receive CFTR modulators. While oropharyngeal swabs are commonly used to test for lower airway pathogens, it is unknown whether Staphylococcus aureus from the oropharynx matches the strain(s) i...