Zinc-Catalyzed Alkyne Oxidation/CH Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines

• Published in: Angewandte Chemie International Edition Vol. 54; no. 28; pp. 8245 - 8249
• Main Authors: Li, Long, Zhou, Bo, Wang, Yong-Heng, Shu, Chao, Pan, Yi-Fei, Lu, Xin, Ye, Long-Wu
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 06.07.2015; WILEY‐VCH Verlag
• Subjects: Acids, Heterocyclic - chemistry; Carbolines - chemistry; Catalysis; heterocycles; homogeneous catalysis; nitrogen oxides; Nitrogen Oxides - chemistry; Oxidation-Reduction; synthetic methods; zinc; Zinc - chemistry; homogeneous catalysis; heterocycles; zinc; nitrogen oxides; synthetic methods

An efficient zinc(II)‐catalyzed alkyne oxidation/CH functionalization sequence was developed, thus leading to highly site‐selective synthesis of a variety of isoquinolones and β‐carbolines. Importantly, in contrast to the well‐established gold‐catalyzed intermolecular alkyne oxidation, over‐oxidati...