Association of sickle cell trait with adverse pregnancy outcomes in a population‐based cohort
Introduction Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non‐Hispanic Black women, including (1) validate...
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Published in | Acta obstetricia et gynecologica Scandinavica Vol. 102; no. 8; pp. 1100 - 1105 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
John Wiley & Sons, Inc
01.08.2023
John Wiley and Sons Inc |
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Abstract | Introduction
Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non‐Hispanic Black women, including (1) validate the associations of SCT with previously reported APOs, (2) test novel associations of SCT with broad spectrum of APOs, and (3) estimate the attributable risk of SCT for implicated APOs.
Material and methods
This is a retrospective analysis of a prospectively designed population‐based cohort. Women/participants were self‐reported non‐Hispanic Black women from the UK Biobank (UKB). SCT status was determined based on heterozygous Glu6Val in the HBB gene. Several APOs were studied, including four previously reported SCT‐associated APOs (preeclampsia, bacteriuria, pregnancy loss, and preterm delivery), and broad conditions related to pregnancy, childbirth, and the puerperium. APOs were curated by experts’ peer review and consensus processes. Associations of SCT with APOs were tested by estimating its relative risk and 95% confidence interval (95% CI), adjusting for number of live births and age at first birth. Attributable risk proportion (ARP) and population attributable risk proportion (PARP) of SCT to APOs were estimated.
Results
Among the 4057 self‐reported non‐Hispanic Black women with pregnancy records in the UKB, 581 (14.32%) were SCT carriers. For four previously reported SCT‐associated APOs, two were confirmed at a nominal P < 0.05; relative risk (RR) was 2.39 (95% CI 1.09–5.23) for preeclampsia, and 4.85 (95% CI 1.77–13.27) for bacteriuria. SCT contributed substantially to these two APOs among SCT carriers, with attributable risk proportion estimated at 61.00% and 68.96% for preeclampsia and bacteriuria, respectively. SCT also contributed substantially to these two APOs in the population (self‐reported Black UK women), with population attributable risk proportion estimated at 18.30% and 24.14% for preeclampsia and bacteriuria, respectively. In addition, novel associations were found for seven other APOs (nominal P < 0.05).
Conclusions
SCT is significantly associated with APOs in this study and contributes substantially to APOs among self‐reported Black women in the UK. Confirmation of these findings in independent study populations is required.
In this population‐based cohort, sickle cell trait is significantly associated with adverse pregnancy outcomes (APOs), including previously known sickle cell trait‐associated APOs (preeclampsia and bacteriuria) and seven other APOs to be confirmed in future studies. Sickle cell trait contributes substantially to APOs among self‐reported Black women in the UK. |
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AbstractList | Introduction
Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non‐Hispanic Black women, including (1) validate the associations of SCT with previously reported APOs, (2) test novel associations of SCT with broad spectrum of APOs, and (3) estimate the attributable risk of SCT for implicated APOs.
Material and methods
This is a retrospective analysis of a prospectively designed population‐based cohort. Women/participants were self‐reported non‐Hispanic Black women from the UK Biobank (UKB). SCT status was determined based on heterozygous Glu6Val in the HBB gene. Several APOs were studied, including four previously reported SCT‐associated APOs (preeclampsia, bacteriuria, pregnancy loss, and preterm delivery), and broad conditions related to pregnancy, childbirth, and the puerperium. APOs were curated by experts’ peer review and consensus processes. Associations of SCT with APOs were tested by estimating its relative risk and 95% confidence interval (95% CI), adjusting for number of live births and age at first birth. Attributable risk proportion (ARP) and population attributable risk proportion (PARP) of SCT to APOs were estimated.
Results
Among the 4057 self‐reported non‐Hispanic Black women with pregnancy records in the UKB, 581 (14.32%) were SCT carriers. For four previously reported SCT‐associated APOs, two were confirmed at a nominal P < 0.05; relative risk (RR) was 2.39 (95% CI 1.09–5.23) for preeclampsia, and 4.85 (95% CI 1.77–13.27) for bacteriuria. SCT contributed substantially to these two APOs among SCT carriers, with attributable risk proportion estimated at 61.00% and 68.96% for preeclampsia and bacteriuria, respectively. SCT also contributed substantially to these two APOs in the population (self‐reported Black UK women), with population attributable risk proportion estimated at 18.30% and 24.14% for preeclampsia and bacteriuria, respectively. In addition, novel associations were found for seven other APOs (nominal P < 0.05).
Conclusions
SCT is significantly associated with APOs in this study and contributes substantially to APOs among self‐reported Black women in the UK. Confirmation of these findings in independent study populations is required.
In this population‐based cohort, sickle cell trait is significantly associated with adverse pregnancy outcomes (APOs), including previously known sickle cell trait‐associated APOs (preeclampsia and bacteriuria) and seven other APOs to be confirmed in future studies. Sickle cell trait contributes substantially to APOs among self‐reported Black women in the UK. In this population‐based cohort, sickle cell trait is significantly associated with adverse pregnancy outcomes (APOs), including previously known sickle cell trait‐associated APOs (preeclampsia and bacteriuria) and seven other APOs to be confirmed in future studies. Sickle cell trait contributes substantially to APOs among self‐reported Black women in the UK. IntroductionSickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non‐Hispanic Black women, including (1) validate the associations of SCT with previously reported APOs, (2) test novel associations of SCT with broad spectrum of APOs, and (3) estimate the attributable risk of SCT for implicated APOs.Material and methodsThis is a retrospective analysis of a prospectively designed population‐based cohort. Women/participants were self‐reported non‐Hispanic Black women from the UK Biobank (UKB). SCT status was determined based on heterozygous Glu6Val in the HBB gene. Several APOs were studied, including four previously reported SCT‐associated APOs (preeclampsia, bacteriuria, pregnancy loss, and preterm delivery), and broad conditions related to pregnancy, childbirth, and the puerperium. APOs were curated by experts’ peer review and consensus processes. Associations of SCT with APOs were tested by estimating its relative risk and 95% confidence interval (95% CI), adjusting for number of live births and age at first birth. Attributable risk proportion (ARP) and population attributable risk proportion (PARP) of SCT to APOs were estimated.ResultsAmong the 4057 self‐reported non‐Hispanic Black women with pregnancy records in the UKB, 581 (14.32%) were SCT carriers. For four previously reported SCT‐associated APOs, two were confirmed at a nominal P < 0.05; relative risk (RR) was 2.39 (95% CI 1.09–5.23) for preeclampsia, and 4.85 (95% CI 1.77–13.27) for bacteriuria. SCT contributed substantially to these two APOs among SCT carriers, with attributable risk proportion estimated at 61.00% and 68.96% for preeclampsia and bacteriuria, respectively. SCT also contributed substantially to these two APOs in the population (self‐reported Black UK women), with population attributable risk proportion estimated at 18.30% and 24.14% for preeclampsia and bacteriuria, respectively. In addition, novel associations were found for seven other APOs (nominal P < 0.05).ConclusionsSCT is significantly associated with APOs in this study and contributes substantially to APOs among self‐reported Black women in the UK. Confirmation of these findings in independent study populations is required. Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains inconsistent. The objectives of this study are to test associations of SCT with APOs in non-Hispanic Black women, including (1) validate the associations of SCT with previously reported APOs, (2) test novel associations of SCT with broad spectrum of APOs, and (3) estimate the attributable risk of SCT for implicated APOs. This is a retrospective analysis of a prospectively designed population-based cohort. Women/participants were self-reported non-Hispanic Black women from the UK Biobank (UKB). SCT status was determined based on heterozygous Glu6Val in the HBB gene. Several APOs were studied, including four previously reported SCT-associated APOs (preeclampsia, bacteriuria, pregnancy loss, and preterm delivery), and broad conditions related to pregnancy, childbirth, and the puerperium. APOs were curated by experts' peer review and consensus processes. Associations of SCT with APOs were tested by estimating its relative risk and 95% confidence interval (95% CI), adjusting for number of live births and age at first birth. Attributable risk proportion (ARP) and population attributable risk proportion (PARP) of SCT to APOs were estimated. Among the 4057 self-reported non-Hispanic Black women with pregnancy records in the UKB, 581 (14.32%) were SCT carriers. For four previously reported SCT-associated APOs, two were confirmed at a nominal P < 0.05; relative risk (RR) was 2.39 (95% CI 1.09-5.23) for preeclampsia, and 4.85 (95% CI 1.77-13.27) for bacteriuria. SCT contributed substantially to these two APOs among SCT carriers, with attributable risk proportion estimated at 61.00% and 68.96% for preeclampsia and bacteriuria, respectively. SCT also contributed substantially to these two APOs in the population (self-reported Black UK women), with population attributable risk proportion estimated at 18.30% and 24.14% for preeclampsia and bacteriuria, respectively. In addition, novel associations were found for seven other APOs (nominal P < 0.05). SCT is significantly associated with APOs in this study and contributes substantially to APOs among self-reported Black women in the UK. Confirmation of these findings in independent study populations is required. |
Author | Wei, Jun Caplan, Michael S. Rifkin, Andrew S. Helfand, Brian T. Ouyang, David W. Shi, Zhuqing Xu, Jianfeng Zheng, S. Lilly Hulsizer, Joseph Morgan, Jessica |
AuthorAffiliation | 2 Department of Surgery NorthShore University HealthSystem Evanston Illinois USA 6 Department of Pediatrics University of Chicago Pritzker School of Medicine Chicago Illinois USA 1 Program for Personalized Cancer Care NorthShore University HealthSystem Evanston Illinois USA 3 Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA 5 Department of Pediatrics NorthShore University HealthSystem Evanston Illinois USA 4 Department of Obstetrics and Gynecology NorthShore University HealthSystem Evanston Illinois USA |
AuthorAffiliation_xml | – name: 3 Department of Surgery University of Chicago Pritzker School of Medicine Chicago Illinois USA – name: 2 Department of Surgery NorthShore University HealthSystem Evanston Illinois USA – name: 4 Department of Obstetrics and Gynecology NorthShore University HealthSystem Evanston Illinois USA – name: 6 Department of Pediatrics University of Chicago Pritzker School of Medicine Chicago Illinois USA – name: 5 Department of Pediatrics NorthShore University HealthSystem Evanston Illinois USA – name: 1 Program for Personalized Cancer Care NorthShore University HealthSystem Evanston Illinois USA |
Author_xml | – sequence: 1 givenname: Joseph surname: Hulsizer fullname: Hulsizer, Joseph organization: NorthShore University HealthSystem – sequence: 2 givenname: Andrew S. surname: Rifkin fullname: Rifkin, Andrew S. organization: NorthShore University HealthSystem – sequence: 3 givenname: Zhuqing surname: Shi fullname: Shi, Zhuqing organization: NorthShore University HealthSystem – sequence: 4 givenname: Jun surname: Wei fullname: Wei, Jun organization: NorthShore University HealthSystem – sequence: 5 givenname: S. Lilly surname: Zheng fullname: Zheng, S. Lilly organization: NorthShore University HealthSystem – sequence: 6 givenname: Brian T. surname: Helfand fullname: Helfand, Brian T. organization: University of Chicago Pritzker School of Medicine – sequence: 7 givenname: Jessica surname: Morgan fullname: Morgan, Jessica organization: NorthShore University HealthSystem – sequence: 8 givenname: David W. surname: Ouyang fullname: Ouyang, David W. organization: NorthShore University HealthSystem – sequence: 9 givenname: Michael S. surname: Caplan fullname: Caplan, Michael S. organization: University of Chicago Pritzker School of Medicine – sequence: 10 givenname: Jianfeng orcidid: 0000-0002-1343-8752 surname: Xu fullname: Xu, Jianfeng email: jxu@northshore.org organization: University of Chicago Pritzker School of Medicine |
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Cites_doi | 10.1097/AOG.0000000000002708 10.1136/jech.56.8.606 10.1097/AOG.0000000000002441 10.1055/s-2003-37953 10.1055/s-0039-1695743 10.3390/mi12050519 10.1182/asheducation-2015.1.160 10.1111/bjh.13270 10.1038/s41586-018-0579-z 10.1016/0020-7292(90)90649-6 10.1001/jama.2014.2157 10.1002/ajh.25227 10.1016/0035-9203(54)90101-7 10.1001/jama.2021.23870 10.1016/j.amjmed.2022.03.024 10.1001/jama.1972.03200250044012 10.1016/S0140-6736(12)61229-X 10.1111/bjh.16518 10.3324/haematol.2018.206060 10.1016/S0002-9378(97)70209-6 10.1016/j.ajog.2006.02.027 10.1016/S0140-6736(10)61029-X 10.1016/j.amjmed.2008.12.020 10.1056/NEJM197905033001801 10.1016/j.ahj.2021.08.019 |
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Keywords | common diseases complications sickle cell trait diabetes hypertension |
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References | 1979; 300 2015; 1 2018; 562 2019; 9 1990; 33 2015; 169 2002; 56 1997; 177 2019; 104 1954; 48 2006; 194 2021; 242 2013; 381 2022; 135 2014; 311 2018; 131 2020; 190 2018; 132 2021; 12 2022 2010; 376 2009; 122 2018; 93 1972; 221 2022; 327 2003; 20 e_1_2_12_4_1 e_1_2_12_3_1 e_1_2_12_6_1 e_1_2_12_5_1 e_1_2_12_19_1 e_1_2_12_18_1 e_1_2_12_2_1 e_1_2_12_17_1 e_1_2_12_16_1 e_1_2_12_20_1 e_1_2_12_21_1 e_1_2_12_22_1 e_1_2_12_23_1 e_1_2_12_24_1 e_1_2_12_25_1 e_1_2_12_26_1 e_1_2_12_27_1 e_1_2_12_15_1 e_1_2_12_14_1 e_1_2_12_13_1 e_1_2_12_12_1 e_1_2_12_8_1 e_1_2_12_11_1 e_1_2_12_7_1 e_1_2_12_10_1 e_1_2_12_9_1 |
References_xml | – volume: 135 start-page: e279 year: 2022 end-page: e287 article-title: Sickle cell trait and risk for common diseases: evidence from the UK biobank publication-title: Am J Med – volume: 122 start-page: 507 year: 2009 end-page: 512 article-title: Complications associated with sickle cell trait: a brief narrative review publication-title: Am J Med – volume: 311 start-page: 1495 year: 2014 end-page: 1496 article-title: Sickle cell trait—neglected opportunities in the era of genomic medicine publication-title: Jama – volume: 562 start-page: 203 year: 2018 end-page: 209 article-title: The UK biobank resource with deep phenotyping and genomic data publication-title: Nature – volume: 93 start-page: 1227 year: 2018 end-page: 1235 article-title: Oxygen‐dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments publication-title: Am J Hematol – volume: 242 start-page: 92 year: 2021 end-page: 102 article-title: Reducing disparities in adverse pregnancy outcomes in the United States publication-title: Am Heart J – volume: 56 start-page: 606 year: 2002 end-page: 610 article-title: Impact numbers: measures of risk factor impact on the whole population from case‐control and cohort studies publication-title: J Epidemiol Community Health – volume: 132 start-page: e44 year: 2018 end-page: e52 article-title: ACOG Committee Opinion No. 743: low‐dose aspirin use during pregnancy publication-title: Obstet Gynecol – volume: 327 start-page: 421 year: 2022 end-page: 422 article-title: Mitigating the long‐term health risks of adverse pregnancy outcomes publication-title: Jama – volume: 194 start-page: 1604 year: 2006 end-page: 1608 article-title: Pregnancy loss after first‐trimester viability in women with sickle cell trait: time for a reappraisal? publication-title: Am J Obstet Gynecol – volume: 221 start-page: 1404 year: 1972 end-page: 1405 article-title: Low birth weight in babies born to mothers with sickle cell trait publication-title: Jama – volume: 9 start-page: e346 year: 2019 end-page: e352 article-title: Adverse pregnancy outcomes in women with sickle cell trait publication-title: AJP Rep – volume: 12 start-page: 519 year: 2021 article-title: Techniques for the detection of sickle cell disease: a review publication-title: Micromachines (Basel) – volume: 190 start-page: 328 year: 2020 end-page: 335 article-title: Pregnancy in sickle cell trait: what we do and don't know publication-title: Br J Haematol – volume: 33 start-page: 19 year: 1990 end-page: 21 article-title: Sickle trait and its association with birthweight and urinary tract infections in pregnancy publication-title: Int J Gynaecol Obstet – year: 2022 – volume: 104 start-page: 1106 year: 2019 end-page: 1111 article-title: The carrier state for sickle cell disease is not completely harmless publication-title: Haematologica – volume: 300 start-page: 1001 year: 1979 end-page: 1005 article-title: Clinical implications of sickle‐cell trait and glucose‐6‐phosphate dehydrogenase deficiency in hospitalized black male patients publication-title: N Engl J Med – volume: 20 start-page: 41 year: 2003 end-page: 48 article-title: Pregnant women with the sickle cell trait are not at increased risk for developing preeclampsia publication-title: Am J Perinatol – volume: 131 start-page: 328 year: 2018 end-page: 335 article-title: Racial disparities in adverse pregnancy outcomes and psychosocial stress publication-title: Obstet Gynecol – volume: 177 start-page: 425 year: 1997 end-page: 428 article-title: Women with sickle cell trait are at increased risk for preeclampsia publication-title: Am J Obstet Gynecol – volume: 1 start-page: 160 year: 2015 end-page: 167 article-title: Sickle cell trait diagnosis: clinical and social implications publication-title: Hematol Am Soc Hematol Educ Program – volume: 48 start-page: 312 year: 1954 end-page: 318 article-title: The distribution of the sickle‐cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria publication-title: Trans R Soc Trop Med Hyg – volume: 381 start-page: 142 year: 2013 end-page: 151 article-title: Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model‐based map and population estimates publication-title: Lancet – volume: 376 start-page: 2018 year: 2010 end-page: 2031 article-title: Sickle‐cell disease publication-title: Lancet – volume: 169 start-page: 129 year: 2015 end-page: 137 article-title: Pregnancy outcome in patients with sickle cell disease in the UK—a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease publication-title: Br J Haematol – ident: e_1_2_12_27_1 doi: 10.1097/AOG.0000000000002708 – ident: e_1_2_12_21_1 doi: 10.1136/jech.56.8.606 – ident: e_1_2_12_3_1 doi: 10.1097/AOG.0000000000002441 – ident: e_1_2_12_16_1 doi: 10.1055/s-2003-37953 – ident: e_1_2_12_17_1 doi: 10.1055/s-0039-1695743 – ident: e_1_2_12_24_1 doi: 10.3390/mi12050519 – ident: e_1_2_12_23_1 doi: 10.1182/asheducation-2015.1.160 – ident: e_1_2_12_5_1 doi: 10.1111/bjh.13270 – ident: e_1_2_12_19_1 doi: 10.1038/s41586-018-0579-z – ident: e_1_2_12_13_1 doi: 10.1016/0020-7292(90)90649-6 – ident: e_1_2_12_26_1 doi: 10.1001/jama.2014.2157 – ident: e_1_2_12_9_1 doi: 10.1002/ajh.25227 – ident: e_1_2_12_25_1 doi: 10.1016/0035-9203(54)90101-7 – ident: e_1_2_12_2_1 doi: 10.1001/jama.2021.23870 – ident: e_1_2_12_10_1 doi: 10.1016/j.amjmed.2022.03.024 – ident: e_1_2_12_12_1 doi: 10.1001/jama.1972.03200250044012 – ident: e_1_2_12_8_1 doi: 10.1016/S0140-6736(12)61229-X – ident: e_1_2_12_6_1 – ident: e_1_2_12_18_1 doi: 10.1111/bjh.16518 – ident: e_1_2_12_11_1 doi: 10.3324/haematol.2018.206060 – ident: e_1_2_12_14_1 doi: 10.1016/S0002-9378(97)70209-6 – ident: e_1_2_12_15_1 doi: 10.1016/j.ajog.2006.02.027 – ident: e_1_2_12_20_1 doi: 10.1016/S0140-6736(10)61029-X – ident: e_1_2_12_7_1 doi: 10.1016/j.amjmed.2008.12.020 – ident: e_1_2_12_22_1 doi: 10.1056/NEJM197905033001801 – ident: e_1_2_12_4_1 doi: 10.1016/j.ahj.2021.08.019 |
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Snippet | Introduction
Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but... Sickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but remains... IntroductionSickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but... INTRODUCTIONSickle cell trait (SCT) is common in African descendants. Its association with several adverse pregnancy outcomes (APOs) has been reported but... In this population‐based cohort, sickle cell trait is significantly associated with adverse pregnancy outcomes (APOs), including previously known sickle cell... |
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SubjectTerms | Bacteriuria Black people Clinical outcomes common diseases complications Diabetes Female Health risks Hispanic people Humans hypertension Infant, Newborn Original Postpartum period Pre-Eclampsia Preeclampsia Pregnancy Pregnancy Outcome Retrospective Studies Risk Factors Sickle cell disease sickle cell trait Sickle Cell Trait - complications Sickle Cell Trait - epidemiology Sickle Cell Trait - genetics Womens health |
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Title | Association of sickle cell trait with adverse pregnancy outcomes in a population‐based cohort |
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