Emerging roles of PLCγ1 in endothelial biology
Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLCγ1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kin...
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| Published in | Science signaling Vol. 14; no. 694 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
03.08.2021
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLCγ1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kinases. The distinct vascular phenotypes in PLCγ1-deficient animal models and the gain-of-function mutations of PLCγ1 found in human endothelial cancers point to a major physiological role of PLCγ1 in the endothelial system. In this review, we discuss aspects of physiological and molecular function centering around PLCγ1 in the context of endothelial cells and provide a perspective for future investigation. |
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| AbstractList | Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLCγ1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kinases. The distinct vascular phenotypes in PLCγ1-deficient animal models and the gain-of-function mutations of PLCγ1 found in human endothelial cancers point to a major physiological role of PLCγ1 in the endothelial system. In this review, we discuss aspects of physiological and molecular function centering around PLCγ1 in the context of endothelial cells and provide a perspective for future investigation. |
| Author | Chen, Dongying Simons, Michael |
| Author_xml | – sequence: 1 givenname: Dongying orcidid: 0000-0003-0167-3285 surname: Chen fullname: Chen, Dongying organization: Yale Cardiovascular Research Center, Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA – sequence: 2 givenname: Michael orcidid: 0000-0003-0348-7734 surname: Simons fullname: Simons, Michael email: michael.simons@yale.edu organization: Yale Cardiovascular Research Center, Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA. michael.simons@yale.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34344833$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. |
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| Title | Emerging roles of PLCγ1 in endothelial biology |
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