A Murine Model of Waning Scrub Typhus Cross-Protection between Heterologous Strains of Orientia tsutsugamushi

• Published in: Pathogens (Basel) Vol. 11; no. 5; p. 512
• Main Authors: Mendell, Nicole L, Xu, Guang, Shelite, Thomas R, Bouyer, Donald H, Walker, David H
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2022; MDPI
• Subjects: Animal models; Antibodies; Body weight; Body weight loss; Cross-protection; Erythema; Etiology; Fatalities; hematogenous model; Homology; Illnesses; Immune response; Immune system; Immunity; Infections; intradermal; Kidneys; Laboratories; Lethal dose; Organs; Orientia; Orientia tsutsugamushi; Pathogens; Scrub typhus; Spleen; Strains (organisms); sublethal; Typhus; Vaccines; Weight loss; sublethal; hematogenous model; immunity; Orientia; cross-protection; intradermal; scrub typhus

, the etiologic agent of the life-threatening febrile disease scrub typhus, is an obligately intracellular small coccobacillary bacterium belonging to the family Rickettsiaceae and is transmitted by the parasitic larval stage of trombiculid mites. Progress towards a vaccine for protection against sc...