In vivo neuronal synthesis and axonal transport of Kunitz protease inhibitor (KPI)-containing forms of the amyloid precursor protein

• Published in: Journal of neurochemistry Vol. 63; no. 5; p. 1971
• Main Authors: Moya, K L, Confaloni, A M, Allinquant, B
• Format: Journal Article
• Language: English
• Published: England 01.11.1994
• Subjects: Amyloid beta-Protein Precursor - analysis; Amyloid beta-Protein Precursor - metabolism; Amyloid beta-Protein Precursor - pharmacokinetics; Animals; Axons - chemistry; Axons - metabolism; Axons - physiology; Biological Transport - physiology; Blotting, Western; Cricetinae; Mesocricetus; Neurons - chemistry; Neurons - metabolism; Neurons - physiology; Trypsin Inhibitor, Kunitz Soybean - analysis

We have shown previously that the amyloid precursor protein (APP) is synthesized in retinal ganglion cells and is rapidly transported down the axons, and that different molecular weight forms of the precursor have different developmental time courses. Some APP isoforms contain a Kunitz protease inhi...