The Diagnostic Value of Interleukin‐2 and Interferon‐γ Induced by Fusion Protein (ESAT‐6/CFP‐10/Rv1985c) for Active Mycobacterium tuberculosis Infection

• Published in: Journal of clinical laboratory analysis Vol. 39; no. 5; pp. e70010 - n/a
• Main Authors: Zhao, Zhipeng, Li, Runqing, Zhao, Xiuying, Wang, Yujie, Lin, Minggui, Wei, Qian, Li, Xiaochen, Xiong, Pan
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2025; John Wiley and Sons Inc
• Subjects: active tuberculosis (ATB); Adult; Aged; Antigens; Antigens, Bacterial - metabolism; Autoimmune diseases; Bacterial Proteins - metabolism; Cytokines; Deoxyribonucleic acid; DNA; extra‐pulmonary tuberculosis; Female; Fusion protein; Humans; Infections; Interferon; Interferon-gamma - blood; Interferon-gamma - metabolism; Interferon-gamma Release Tests; interferon‐γ (IFN‐γ); Interleukin 2; Interleukin-2 - blood; Interleukin‐2 (IL‐2); Male; Middle Aged; Mycobacterium tuberculosis; Proteins; Recombinant Fusion Proteins - metabolism; Sensitivity and Specificity; Tuberculosis; Tuberculosis - blood; Tuberculosis - diagnosis; Young Adult; Beijing China; United States > US; China; Interleukin‐2 (IL‐2); interferon‐γ (IFN‐γ); active tuberculosis (ATB); extra‐pulmonary tuberculosis; tuberculosis

ABSTRACT Objective This study aimed to evaluate the diagnostic ability of interleukin 2 (IL‐2) and interferon gamma (IFN‐γ) release assay induced by the fusion protein (ESAT‐6/CFP‐10/Rv1985c) for detecting active tuberculosis (ATB) in clinically visiting patients. Methods A total of 970 subjects (21...