N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex
Many neuronal disorders such as lissencephaly, epilepsy, and schizophrenia are caused by the abnormal migration of neurons in the developing brain. The role of the actin cytoskeleton in neuronal migration disorders has in large part remained elusive. Here we show that the F-actin depolymerizing fact...
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| Published in | Genes & development Vol. 21; no. 18; pp. 2347 - 2357 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Cold Spring Harbor Laboratory Press
15.09.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Many neuronal disorders such as lissencephaly, epilepsy, and schizophrenia are caused by the abnormal migration of neurons in the developing brain. The role of the actin cytoskeleton in neuronal migration disorders has in large part remained elusive. Here we show that the F-actin depolymerizing factor n-cofilin controls cell migration and cell cycle progression in the cerebral cortex. Loss of n-cofilin impairs radial migration, resulting in the lack of intermediate cortical layers. Neuronal progenitors in the ventricular zone show increased cell cycle exit and exaggerated neuronal differentiation, leading to the depletion of the neuronal progenitor pool. These results demonstrate that mutations affecting regulators of the actin cytoskeleton contribute to the pathology of cortex development. |
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| AbstractList | Many neuronal disorders such as lissencephaly, epilepsy, and schizophrenia are caused by the abnormal migration of neurons in the developing brain. The role of the actin cytoskeleton in neuronal migration disorders has in large part remained elusive. Here we show that the F-actin depolymerizing factor n-cofilin controls cell migration and cell cycle progression in the cerebral cortex. Loss of n-cofilin impairs radial migration, resulting in the lack of intermediate cortical layers. Neuronal progenitors in the ventricular zone show increased cell cycle exit and exaggerated neuronal differentiation, leading to the depletion of the neuronal progenitor pool. These results demonstrate that mutations affecting regulators of the actin cytoskeleton contribute to the pathology of cortex development. |
| Author | Gurniak, Christine B Bellenchi, Gian Carlo Perlas, Emerald Middei, Silvia Ammassari-Teule, Martine Witke, Walter |
| AuthorAffiliation | 1 Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), 00015 Monterotondo, Italy 3 Consiglio Nazionale delle Ricerche (CNR) Institute for Neuroscience, Santa Lucia Foundation, 00143 Rome, Italy 2 Department of Cell Biology and Neuroscience, Instituto Superiore di Sanità, 00161 Rome, Italy |
| AuthorAffiliation_xml | – name: 2 Department of Cell Biology and Neuroscience, Instituto Superiore di Sanità, 00161 Rome, Italy – name: 1 Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), 00015 Monterotondo, Italy – name: 3 Consiglio Nazionale delle Ricerche (CNR) Institute for Neuroscience, Santa Lucia Foundation, 00143 Rome, Italy |
| Author_xml | – sequence: 1 givenname: Gian Carlo surname: Bellenchi fullname: Bellenchi, Gian Carlo organization: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), 00015, Monterotondo, Italy – sequence: 2 givenname: Christine B surname: Gurniak fullname: Gurniak, Christine B – sequence: 3 givenname: Emerald surname: Perlas fullname: Perlas, Emerald – sequence: 4 givenname: Silvia surname: Middei fullname: Middei, Silvia – sequence: 5 givenname: Martine surname: Ammassari-Teule fullname: Ammassari-Teule, Martine – sequence: 6 givenname: Walter surname: Witke fullname: Witke, Walter |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17875668$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Actin Cytoskeleton - metabolism Animals Animals, Newborn Brain Diseases - embryology Cell Cycle - genetics Cell Movement Cerebral Cortex - cytology Cerebral Cortex - embryology Cofilin 1 - genetics Cofilin 1 - physiology Destrin - genetics Destrin - physiology Mice Mice, Transgenic Models, Biological Neurites - metabolism Neurons - physiology Research Paper |
| Title | N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex |
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