Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis

• Published in: European journal of internal medicine Vol. 118; pp. 49 - 58
• Main Authors: Arias-de la Rosa, I, Ruiz-Ponce, M, Cuesta-López, L, Pérez-Sánchez, C, Leiva-Cepas, F, Gahete, MD, Navarro, P, Ortega, R, Cordoba, J, Pérez-Pampin, E, González, A, Lucendo, AJ, Collantes-Estévez, E, López-Pedrera, Ch, Escudero-Contreras, A, Barbarroja, N
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2023
• Subjects: ACPAs; Animals; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - drug therapy; Autoantibodies; Cross-Sectional Studies; Humans; Inflammation; Liver disease risk; Liver Diseases; Longitudinal Studies; Methotrexate - therapeutic use; Mice; NAFLD; Obesity; Peptides, Cyclic; Proximity extension assay; Rheumatoid arthritis; Liver disease risk; NAFLD; Inflammation; ACPAs; Proximity extension assay; Rheumatoid arthritis

•Liver alterations in RA can occur independently of obesity or diabetes.•NAFLD in RA is related to the systemic inflammatory burden, disease activity, and levels of autoantibodies.•Liver of RA patients might be characterized by inflammation due to the infiltration of T and B cells and macrophages.•A...