Incorporating Innovative Techniques Toward Extrapolation and Efficient Pediatric Drug Development - Gamalo-Siebers, Margaret; Hampson, Lisa; Kordy, Kattayoun; Weber, Sebastian; Nelson, Robert M.; Portman, Ronald (Therapeutic innovation & regulatory science, 2019)
Keywords: Adolescent; Bayes Theorem; Child; Children; Clinical trials; Clinical Trials as Topic - methods; Deep Learning; Drug development; Drug Development - methods; Drug Safety and Pharmacovigilance; Ethical standards; Extrapolation; Humans; Mathematical analysis; Pediatrics; Pharmacotherapy; Pharmacy; Research Design; Special Section: Pediatric Therapeutic Development: Original Article; United States; United States; pediatric trials; extrapolation; hierarchical model; Bayesian methods; matching