Molecular Cloning and Characterization of the Human PED/PEA-15 Gene Promoter Reveal Antagonistic Regulation by Hepatocyte Nuclear Factor 4α and Chicken Ovalbumin Upstream Promoter Transcription Factor II

• Published in: The Journal of biological chemistry Vol. 283; no. 45; pp. 30970 - 30979
• Main Authors: Ungaro, Paola, Teperino, Raffaele, Mirra, Paola, Cassese, Angela, Fiory, Francesca, Perruolo, Giuseppe, Miele, Claudia, Laakso, Markku, Formisano, Pietro, Beguinot, Francesco
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 07.11.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Transcription, Chromatin, and Epigenetics

Overexpression of the ped/pea-15 gene in mice impairs glucose tolerance and leads to diabetes in conjunction with high fat diet treatment. PED/PEA-15 is also overexpressed in type 2 diabetics as well as in euglycemic offspring from these subjects. The cause(s) of this abnormality remains unclear. In...