Regulation of GLUT4 gene expression by SREBP-1c in adipocytes

• Published in: Biochemical journal Vol. 399; no. 1; pp. 131 - 139
• Main Authors: Im, Seung-Soon, Kwon, Sool-Ki, Kang, Seung-Youn, Kim, Tae-Hyun, Kim, Ha-Il, Hur, Man-Wook, Kim, Kyung-Sup, Ahn, Yong-Ho
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 01.10.2006
• Subjects: 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - metabolism; Animals; Cell Differentiation; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - metabolism; Eating; Fasting; Gene Expression Regulation - drug effects; Glucose Transporter Type 4 - genetics; Humans; Insulin - pharmacology; Male; Mice; Promoter Regions, Genetic; Rats; Response Elements - genetics; Sp1 Transcription Factor - metabolism; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Up-Regulation - drug effects

Expression of the GLUT4 (glucose transporter type 4 isoform) gene in adipocytes is subject to hormonal or metabolic control. In the present study, we have characterized an adipose tissue transcription factor that is influenced by fasting/refeeding regimens and insulin. Northern blotting showed that...