Protein Kinase D-mediated Phosphorylation and Nuclear Export of Sphingosine Kinase 2

• Published in: The Journal of biological chemistry Vol. 282; no. 37; pp. 27493 - 27502
• Main Authors: Ding, Guo, Sonoda, Hirofumi, Yu, Huan, Kajimoto, Taketoshi, Goparaju, Sravan K., Jahangeer, Saleem, Okada, Taro, Nakamura, Shun-ichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.09.2007; American Society for Biochemistry and Molecular Biology
• Subjects: Active Transport, Cell Nucleus; Animals; Cell Nucleus - metabolism; Chlorocebus aethiops; COS Cells; HeLa Cells; Humans; Nuclear Export Signals; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Protein Kinase C - physiology; Serine - metabolism; Tetradecanoylphorbol Acetate - pharmacology

Sphingosine kinase (SPHK) is a key enzyme producing important messenger sphingosine 1-phosphate and is implicated in cell proliferation and suppression of apoptosis. Because the extent of agonist-induced activation of SPHK is modest, signaling via SPHK may be regulated through its localization at sp...