A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling ‘low risk’ patients with penicillin allergy by non-allergy healthcare professionals (SPACE study): Implications for healthcare systems

• Published in: The Journal of infection Vol. 88; no. 3; pp. 106116 - None
• Main Authors: Krishna, Mamidipudi Thirumala, Bhogal, Rashmeet, Ng, Bee Yean, Kildonaviciute, Kornelija, Jani, Yogini H., Williams, Iestyn, Sandoe, Jonathan A.T., Pollard, Rachel, Jones, Nicola, Dunsmure, Louise, Powell, Neil, Hullur, Chidanand, Balaji, Ariyur, Moriarty, Catherine, Jackson, Beverley, Warner, Amena, Daniels, Ron, West, Robert, Thomas, Caroline, Misbah, Siraj A., Savic, Louise
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2024; W.B. Saunders
• Subjects: Anti-Bacterial Agents - adverse effects; Antimicrobial resistance; Delivery of Health Care; Direct oral penicillin challenge; Drug Hypersensitivity - diagnosis; Feasibility Studies; High risk; Humans; Hypersensitivity; Low risk; Penicillin allergy; Penicillins - adverse effects; Risk stratification; Skin Tests; High risk; Direct oral penicillin challenge; Antimicrobial resistance; Low risk; Penicillin allergy; Risk stratification

The huge burden of inaccurate penicillin allergy labels (PALs) is an important driver of antimicrobial resistance. This is magnified by insufficient allergy specialists and lack of ‘point-of-care’ tests. We investigated the feasibility of non-allergy healthcare professionals (HCPs) delivering direct...