Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 235; pp. 1 - 14
• Main Authors: Chiva-Blanch, Gemma, Peña, Esther, Cubedo, Judit, García-Arguinzonis, Maisa, Pané, Adriana, Gil, Pedro A, Perez, Antonio, Ortega, Emilio, Padró, Teresa, Badimon, Lina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2021
• Subjects: 2DE; bone marrow; cardiovascular disease; casein kinase 2α; CFT; clot formation time; clotting time; CSK2α; CVD; heat shock protein A8; heat shock protein90; Hsp90; HSPA8; induced platelet aggregation; IPA; local regression model; LOESS; MALDI-TOF; mass spectrometry; matrix-assisted laser desorption/ionization time-of-flight; maximum clot firmness; MCF; peptide mass fingerprinting; platelet-rich plasma; PMF; PP1Cɣ; protein phosphatase 1Cɣ; PRP; room temperature; two-dimensional electrophoresis; HSPA8; RT; MALDI-TOF; MS; PMF; BM; CSK2α; PRP; CVD; CFT; Hsp90; CT; LOESS; MCF; 2DE; IPA; PP1Cɣ; room temperature; induced platelet aggregation; casein kinase 2α; heat shock protein90; matrix-assisted laser desorption/ionization time-of-flight; two-dimensional electrophoresis; clot formation time; protein phosphatase 1Cɣ; mass spectrometry; local regression model; heat shock protein A8; maximum clot firmness; cardiovascular disease; clotting time; platelet-rich plasma; bone marrow; peptide mass fingerprinting

The molecular understanding of the pathophysiological changes elicited by diabetes in platelets may help in further elucidating the involvement of this pseudo-cell in the increased risk of developing cardiovascular disease and thrombosis in diabetic subjects. We aimed to investigate the differential...